ENZYME entry: EC 3.5.4.5

Accepted Name
Cytidine deaminase.
Alternative Name(s)
(Deoxy)cytidine deaminase.
Cytidine aminohydrolase.
Cytosine nucleoside deaminase.
Reaction catalysed
  • Cytidine + H(2)O <=> uridine + NH(3)
  • 2'-deoxycytidine + H(2)O <=> 2'-deoxyuridine + NH(3)
Cofactor(s)
Zinc.
Comment(s)
  • Catalyzes the deamination of cytidine and 2'-deoxycytidine with similar efficiencies.
  • The enzyme, which is widely distributed among organisms, is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
  • Formerly EC 3.5.4.14.
Cross-references
PROSITEPDOC00702
BRENDA3.5.4.5
EC2PDB3.5.4.5
ExplorEnz3.5.4.5
PRIAM enzyme-specific profiles3.5.4.5
KEGG Ligand Database for Enzyme Nomenclature3.5.4.5
IUBMB Enzyme Nomenclature3.5.4.5
IntEnz3.5.4.5
MEDLINEFind literature relating to 3.5.4.5
MetaCyc3.5.4.5
UniProtKB/Swiss-Prot
O65896, CDA1_ARATH;  O65571, CDA2_ARATH;  Q9S847, CDA3_ARATH;  
Q9S7L8, CDA5_ARATH;  Q9SU86, CDA6_ARATH;  Q9SU87, CDA7_ARATH;  
Q9XEX4, CDA8_ARATH;  A3N1Z1, CDD_ACTP2;  B3GYC3, CDD_ACTP7;  
B0BQT2, CDD_ACTPJ;  A6VLF5, CDD_ACTSZ;  A0KJH4, CDD_AERHH;  
A4SNI2, CDD_AERS4;  Q9KD53, CDD_BACHD;  P19079, CDD_BACSU;  
A8AE87, CDD_CITK8;  A7MLJ4, CDD_CROS8;  Q54I82, CDD_DICDI;  
A7ZNW5, CDD_ECO24;  B7UFF9, CDD_ECO27;  B7MF55, CDD_ECO45;  
B7LA09, CDD_ECO55;  Q8X648, CDD_ECO57;  B5YW75, CDD_ECO5E;  
B7NMA8, CDD_ECO7I;  B7MXF5, CDD_ECO81;  B7M4Y8, CDD_ECO8A;  
C4ZSM3, CDD_ECOBW;  B1X7N2, CDD_ECODH;  A8A204, CDD_ECOHS;  
A1AD04, CDD_ECOK1;  Q0TFU8, CDD_ECOL5;  Q8FFV3, CDD_ECOL6;  
B1IYC6, CDD_ECOLC;  P0ABF6, CDD_ECOLI;  B7NCH2, CDD_ECOLU;  
B6I8J3, CDD_ECOSE;  B1LKP0, CDD_ECOSM;  Q1R9T0, CDD_ECOUT;  
C5BCM4, CDD_EDWI9;  A4WCI1, CDD_ENT38;  B2VIF3, CDD_ERWT9;  
B7LVA3, CDD_ESCF3;  Q7VMJ6, CDD_HAEDU;  Q4QK60, CDD_HAEI8;  
A5UBV9, CDD_HAEIE;  A5UEI7, CDD_HAEIG;  P44325, CDD_HAEIN;  
Q0I4X6, CDD_HISS1;  B0USP2, CDD_HISS2;  P32320, CDD_HUMAN;  
B5XP65, CDD_KLEP3;  A6TBN1, CDD_KLEP7;  Q65RG8, CDD_MANSM;  
P56389, CDD_MOUSE;  P47298, CDD_MYCGE;  P47718, CDD_MYCPI;  
P75051, CDD_MYCPN;  P9WPH2, CDD_MYCTO;  P9WPH3, CDD_MYCTU;  
Q9CP11, CDD_PASMU;  Q6D3B4, CDD_PECAS;  C6DDS7, CDD_PECCP;  
Q7N6K3, CDD_PHOLL;  Q6LRI0, CDD_PHOPR;  B4ESY3, CDD_PROMH;  
Q3IBX5, CDD_PSEHT;  B5EYN3, CDD_SALA4;  A9MKS5, CDD_SALAR;  
Q57MF5, CDD_SALCH;  B5FMZ9, CDD_SALDC;  B5R153, CDD_SALEP;  
B5RC22, CDD_SALG2;  B4TAK5, CDD_SALHS;  B4SY15, CDD_SALNS;  
Q5PE68, CDD_SALPA;  A9N6L3, CDD_SALPB;  C0Q0V4, CDD_SALPC;  
B5BE52, CDD_SALPK;  B4TNP0, CDD_SALSV;  Q8Z5A8, CDD_SALTI;  
Q8ZNM0, CDD_SALTY;  Q09190, CDD_SCHPO;  A8GC32, CDD_SERP5;  
A1S723, CDD_SHEAM;  B8EF35, CDD_SHEB2;  A3D392, CDD_SHEB5;  
A6WLY5, CDD_SHEB8;  A9KXF0, CDD_SHEB9;  Q083S7, CDD_SHEFN;  
B0TQV3, CDD_SHEHH;  A3QDC9, CDD_SHELP;  Q8EDG1, CDD_SHEON;  
A8H5H1, CDD_SHEPA;  A4Y5R0, CDD_SHEPC;  B8CR83, CDD_SHEPW;  
A0KYD1, CDD_SHESA;  A8FWK2, CDD_SHESH;  Q0HHI5, CDD_SHESM;  
Q0HTT9, CDD_SHESR;  A1RL10, CDD_SHESW;  B1KRC5, CDD_SHEWM;  
B2TVV2, CDD_SHIB3;  Q322V3, CDD_SHIBS;  Q32EM3, CDD_SHIDS;  
Q0T2Y0, CDD_SHIF8;  P0ABF7, CDD_SHIFL;  Q3Z062, CDD_SHISS;  
Q2NUD2, CDD_SODGM;  Q9S3M0, CDD_SPOPS;  A5F1V7, CDD_VIBC3;  
A7MVH6, CDD_VIBCB;  Q9KSM5, CDD_VIBCH;  C3LLS7, CDD_VIBCM;  
Q5E4R6, CDD_VIBF1;  B5FEN2, CDD_VIBFM;  Q87Q52, CDD_VIBPA;  
B7VPF1, CDD_VIBSL;  Q8DA31, CDD_VIBVU;  Q7MK48, CDD_VIBVY;  
Q06549, CDD_YEAST;  A7FJK3, CDD_YERP3;  Q1C9U7, CDD_YERPA;  
B2JZJ6, CDD_YERPB;  Q8ZG08, CDD_YERPE;  A9R1B9, CDD_YERPG;  
Q1CGT5, CDD_YERPN;  A4TKN7, CDD_YERPP;  Q66C79, CDD_YERPS;  
B1JPZ5, CDD_YERPY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.4.-
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