ENZYME entry: EC 3.5.4.n2
| Accepted Name |
|---|
| GTP cyclohydrolase (cyclic phosphate forming).
|
| Reaction catalysed |
|---|
| GTP + H(2)O <=> formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate |
| Cofactor(s) |
|---|
| Iron.
|
| Comment(s) |
|---|
- Two C-N bonds are hydrolyzed, releasing formate, with simultaneous
removal of the terminal diphosphate and formation of a cyclic
phosphate group.
- The enzyme is also able to utilize a variety of GTP analogs as
substrates, including GDP, beta,gamma-methylene-GTP and GTP-(gamma-
thio).
|
| Cross-references |
|---|
| UniProtKB/Swiss-Prot |
| Q0W6F5, MPTA1_UNCMA; | Q0W8U7, MPTA2_UNCMA; | Q9Y9I0, MPTA_AERPE; |
| O29088, MPTA_ARCFU; | Q5UXK3, MPTA_HALMA; | B0R6L9, MPTA_HALS3; |
| Q9HNX6, MPTA_HALSA; | Q18F47, MPTA_HALWD; | B1L550, MPTA_KORCO; |
| A6UW53, MPTA_META3; | Q8THJ7, MPTA_METAC; | A7I5I7, MPTA_METB6; |
| Q46D91, MPTA_METBF; | Q12ZQ0, MPTA_METBU; | Q2FNB7, MPTA_METHJ; |
| Q58185, MPTA_METJA; | Q8TY21, MPTA_METKA; | A2SPE0, MPTA_METLZ; |
| A4G0F9, MPTA_METM5; | A9A8Q7, MPTA_METM6; | A6VI22, MPTA_METM7; |
| Q8PXJ6, MPTA_METMA; | A3CXJ6, MPTA_METMJ; | Q6M183, MPTA_METMP; |
| A5UM10, MPTA_METS3; | Q2NI42, MPTA_METST; | O27264, MPTA_METTH; |
| A0B624, MPTA_METTP; | A6UR12, MPTA_METVS; | Q3IR95, MPTA_NATPD; |
| Q6L0A8, MPTA_PICTO; | Q9V1S9, MPTA_PYRAB; | Q8TZZ2, MPTA_PYRFU; |
| O59447, MPTA_PYRHO; | Q5JH75, MPTA_PYRKO; | Q9HJ35, MPTA_THEAC; |
| Q979C3, MPTA_THEVO; |
|
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