ENZYME entry: EC 3.5.99.2

Accepted Name
Aminopyrimidine aminohydrolase.
Alternative Name(s)
Thiaminase.
Thiaminase II.
Reaction catalysed
  • 4-amino-5-aminomethyl-2-methylpyrimidine + H(2)O <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + ammonia
  • Thiamine + H(2)O <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole
Comment(s)
Previously known as thiaminase II, this enzyme is involved in the regeneration of the thiamine pyrimidine from degraded products, rather than in thiamine degradation, and participates in thiamine salvage pathways.
Cross-references
BRENDA3.5.99.2
EC2PDB3.5.99.2
ExplorEnz3.5.99.2
PRIAM enzyme-specific profiles3.5.99.2
KEGG Ligand Database for Enzyme Nomenclature3.5.99.2
IUBMB Enzyme Nomenclature3.5.99.2
IntEnz3.5.99.2
MEDLINEFind literature relating to 3.5.99.2
MetaCyc3.5.99.2
UniProtKB/Swiss-Prot
P25052, TENA_BACSU;  Q2FF32, TENA_STAA3;  Q2FWG0, TENA_STAA8;  
Q2YUL0, TENA_STAAB;  Q5HEA5, TENA_STAAC;  Q99SG3, TENA_STAAM;  
Q7A4F3, TENA_STAAN;  Q6GEY1, TENA_STAAR;  Q6G7L6, TENA_STAAS;  
Q7A0C8, TENA_STAAW;  O54496, TENA_STACT;  Q5HMC7, TENA_STAEQ;  
Q8CNK1, TENA_STAES;  Q4L7X6, TENA_STAHJ;  Q49Z42, TENA_STAS1;  

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