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ENZYME entry: EC 3.5.99.6

Accepted Name
Glucosamine-6-phosphate deaminase.
Alternative Name(s)
GlcN6P deaminase.
Glucosamine phosphate deaminase.
Glucosamine-6-phosphate isomerase.
Phosphoglucosamine isomerase.
Phosphoglucosaminisomerase.
Reaction catalysed
Alpha-D-glucosamine 6-phosphate + H(2)O <=> D-fructose 6-phosphate + NH(3)
Comment(s)
  • Isomerization of the aldose-ketose type converts the -CH(-NH(2))-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH(2)-OH, forming 2-deoxy-2-imino-D-arabino-hexitol which then hydrolyzes to yield fructose 6-phosphate and ammonia.
  • N-acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.
  • Formerly EC 5.3.1.10.
Cross-references
PROSITEPDOC00894
BRENDA3.5.99.6
EC2PDB3.5.99.6
ExplorEnz3.5.99.6
PRIAM enzyme-specific profiles3.5.99.6
KEGG Ligand Database for Enzyme Nomenclature3.5.99.6
IUBMB Enzyme Nomenclature3.5.99.6
IntEnz3.5.99.6
MEDLINEFind literature relating to 3.5.99.6
MetaCyc3.5.99.6
UniProtKB/Swiss-Prot
A0KYQ7, AGAS_SHESA;  O31458, GAMA_BACSU;  A4FV08, GNPI1_BOVIN;  
O97439, GNPI1_GIAIN;  P46926, GNPI1_HUMAN;  Q64422, GNPI1_MESAU;  
O88958, GNPI1_MOUSE;  Q5R8T8, GNPI1_PONAB;  Q17QL1, GNPI2_BOVIN;  
O97440, GNPI2_GIAIN;  Q8TDQ7, GNPI2_HUMAN;  Q9CRC9, GNPI2_MOUSE;  
Q6PA43, GNPI2_XENLA;  A4IHW6, GNPI2_XENTR;  Q16HW7, GNPI_AEDAE;  
Q5TNH5, GNPI_ANOGA;  Q9XVJ2, GNPI_CAEEL;  Q54XK9, GNPI_DICDI;  
Q9VMP9, GNPI_DROME;  Q29NT9, GNPI_DROPS;  Q04802, NAG1_CANAL;  
A9NEX8, NAGB_ACHLI;  A3N353, NAGB_ACTP2;  B3GZ06, NAGB_ACTP7;  
B0BSS6, NAGB_ACTPJ;  A0KIG3, NAGB_AERHH;  A4SPM2, NAGB_AERS4;  
B6EN78, NAGB_ALISL;  A6TVP5, NAGB_ALKMQ;  A8MIX7, NAGB_ALKOO;  
A0JY49, NAGB_ARTS2;  C3P761, NAGB_BACAA;  C3LIR9, NAGB_BACAC;  
A0RI59, NAGB_BACAH;  Q81MH5, NAGB_BACAN;  B7JL33, NAGB_BACC0;  
Q731P4, NAGB_BACC1;  B7IWG6, NAGB_BACC2;  C1EQS8, NAGB_BACC3;  
B7H945, NAGB_BACC4;  B7HN32, NAGB_BACC7;  A7GS78, NAGB_BACCN;  
B9IWR7, NAGB_BACCQ;  Q819D1, NAGB_BACCR;  Q635M6, NAGB_BACCZ;  
Q5LGU0, NAGB_BACFN;  Q64XP2, NAGB_BACFR;  Q9KFQ8, NAGB_BACHD;  
Q6HEB2, NAGB_BACHK;  A8FHS6, NAGB_BACP2;  Q5WHY0, NAGB_BACSK;  
O35000, NAGB_BACSU;  Q8A094, NAGB_BACTN;  A6L7Q8, NAGB_BACV8;  
A7Z975, NAGB_BACVZ;  A9VFF7, NAGB_BACWK;  C5BY94, NAGB_BEUC1;  
B3DQQ9, NAGB_BIFLD;  Q8G4N5, NAGB_BIFLO;  B7GQA1, NAGB_BIFLS;  
Q7VR99, NAGB_BLOFL;  Q0SP13, NAGB_BORAP;  Q662L3, NAGB_BORBP;  
O30564, NAGB_BORBU;  B7J183, NAGB_BORBZ;  B2RZL5, NAGB_BORHD;  
C0ZJF8, NAGB_BREBN;  Q8R5T0, NAGB_CALS4;  B3PBV0, NAGB_CELJU;  
A8AJE0, NAGB_CITK8;  Q97MK9, NAGB_CLOAB;  A7FX73, NAGB_CLOB1;  
C3L2N7, NAGB_CLOB6;  A6M241, NAGB_CLOB8;  B2V163, NAGB_CLOBA;  
B2TL69, NAGB_CLOBB;  A5I5R9, NAGB_CLOBH;  C1FV12, NAGB_CLOBJ;  
B1IKY4, NAGB_CLOBK;  A7GH51, NAGB_CLOBL;  B1KZ07, NAGB_CLOBM;  
A0PYW1, NAGB_CLONN;  Q0TML8, NAGB_CLOP1;  Q8XHP8, NAGB_CLOPE;  
Q0SQB4, NAGB_CLOPS;  Q890L6, NAGB_CLOTE;  Q487K8, NAGB_COLP3;  
C3PJW6, NAGB_CORA7;  Q6NJ91, NAGB_CORDI;  Q8FMI6, NAGB_COREF;  
A4QH44, NAGB_CORGB;  Q8NMD4, NAGB_CORGL;  C4LL80, NAGB_CORK4;  
B1VI88, NAGB_CORU7;  A7MQT6, NAGB_CROS8;  C6C0A2, NAGB_DESAD;  
A7ZJ60, NAGB_ECO24;  B7UKV0, NAGB_ECO27;  B7MFT4, NAGB_ECO45;  
B7L9L4, NAGB_ECO55;  P0A760, NAGB_ECO57;  B5YQM0, NAGB_ECO5E;  
B7NMM9, NAGB_ECO7I;  B7MPI3, NAGB_ECO81;  B7M5J6, NAGB_ECO8A;  
C4ZWF4, NAGB_ECOBW;  B1X6L1, NAGB_ECODH;  A7ZXT7, NAGB_ECOHS;  
A1A8T7, NAGB_ECOK1;  Q0TK13, NAGB_ECOL5;  Q8FJX7, NAGB_ECOL6;  
B1IY50, NAGB_ECOLC;  P0A759, NAGB_ECOLI;  B7N9S4, NAGB_ECOLU;  
B6HYN6, NAGB_ECOSE;  B1LLC0, NAGB_ECOSM;  Q1REP9, NAGB_ECOUT;  
C5BGA6, NAGB_EDWI9;  A4W844, NAGB_ENT38;  P59687, NAGB_ENTFA;  
B2VBN5, NAGB_ERWT9;  B7LKT5, NAGB_ESCF3;  B1YJ30, NAGB_EXIS2;  
C4L2C5, NAGB_EXISA;  Q8REG1, NAGB_FUSNN;  C5D3L0, NAGB_GEOSW;  
Q7VKN1, NAGB_HAEDU;  Q4QP46, NAGB_HAEI8;  A5UB10, NAGB_HAEIE;  
P44538, NAGB_HAEIN;  B8F877, NAGB_HAEPS;  Q0I4B9, NAGB_HAES1;  
Q2S6X5, NAGB_HAHCH;  B8D185, NAGB_HALOH;  B0UUN2, NAGB_HISS2;  
B5XZG9, NAGB_KLEP3;  A6T6C1, NAGB_KLEP7;  Q5FHT1, NAGB_LACAC;  
Q1G817, NAGB_LACDA;  Q047I3, NAGB_LACDB;  A8YTN8, NAGB_LACH4;  
Q74HC4, NAGB_LACJO;  Q9CFA8, NAGB_LACLA;  A2RJR7, NAGB_LACLM;  
Q02Y08, NAGB_LACLS;  Q033M5, NAGB_LACP3;  A9KIR8, NAGB_LACP7;  
Q88ZS6, NAGB_LACPL;  A5VKB2, NAGB_LACRD;  Q1WS60, NAGB_LACS1;  
Q38YK9, NAGB_LACSS;  B1MX39, NAGB_LEUCK;  Q03Z95, NAGB_LEUMM;  
Q92D64, NAGB_LISIN;  C1L1M8, NAGB_LISMC;  Q721K9, NAGB_LISMF;  
B8DEH8, NAGB_LISMH;  Q8Y8E7, NAGB_LISMO;  A0AH75, NAGB_LISW6;  
B1HUU8, NAGB_LYSSC;  P59686, NAGB_LYSSH;  Q65QE8, NAGB_MANSM;  
A6VVU9, NAGB_MARMS;  Q6MSF4, NAGB_MYCMS;  Q8EWM7, NAGB_MYCPE;  
Q98QJ9, NAGB_MYCPU;  A0QU88, NAGB_MYCS2;  Q8ESL6, NAGB_OCEIH;  
Q04G36, NAGB_OENOB;  A6LHV2, NAGB_PARD8;  Q9CMF4, NAGB_PASMU;  
Q6D7J9, NAGB_PECAS;  C6DBY4, NAGB_PECCP;  Q03H91, NAGB_PEDPA;  
Q18AL0, NAGB_PEPD6;  Q7MB61, NAGB_PHOLL;  B2RJ01, NAGB_PORG3;  
Q7MW43, NAGB_PORGI;  Q6AAI8, NAGB_PROAC;  B4ESJ0, NAGB_PROMH;  
B8HAX3, NAGB_PSECP;  Q3ID09, NAGB_PSEHT;  A1SS81, NAGB_PSYIN;  
Q7UVM5, NAGB_RHOBA;  Q0SGH6, NAGB_RHOJR;  C1AW66, NAGB_RHOOB;  
B5EZC1, NAGB_SALA4;  A9MKA9, NAGB_SALAR;  Q57RQ0, NAGB_SALCH;  
B5FNB9, NAGB_SALDC;  B5QWC8, NAGB_SALEP;  B5R824, NAGB_SALG2;  
B4TB82, NAGB_SALHS;  B4SYN7, NAGB_SALNS;  Q5PCH6, NAGB_SALPA;  
A9MUG8, NAGB_SALPB;  C0PWA5, NAGB_SALPC;  B5BCC5, NAGB_SALPK;  
B4TPZ8, NAGB_SALSV;  Q8Z8G0, NAGB_SALTI;  Q8ZQX7, NAGB_SALTY;  
A8GB41, NAGB_SERP5;  B0TTP5, NAGB_SHEHH;  A3QB39, NAGB_SHELP;  
A8FRI2, NAGB_SHESH;  B1KFS0, NAGB_SHEWM;  B2TU53, NAGB_SHIB3;  
Q324M6, NAGB_SHIBS;  Q32IQ2, NAGB_SHIDS;  Q0T6S6, NAGB_SHIF8;  
P59688, NAGB_SHIFL;  Q3Z4C2, NAGB_SHISS;  A7WZ06, NAGB_STAA1;  
A6TZ46, NAGB_STAA2;  Q2FJ71, NAGB_STAA3;  Q2G0K8, NAGB_STAA8;  
A5IQC3, NAGB_STAA9;  Q2YS95, NAGB_STAAB;  Q5HIA6, NAGB_STAAC;  
A6QEM2, NAGB_STAAE;  P65512, NAGB_STAAM;  P99125, NAGB_STAAN;  
Q6GJA0, NAGB_STAAR;  Q6GBR8, NAGB_STAAS;  A8YZR7, NAGB_STAAT;  
P65513, NAGB_STAAW;  Q5HRH8, NAGB_STAEQ;  Q8CTR3, NAGB_STAES;  
Q4L9T8, NAGB_STAHJ;  Q49VB6, NAGB_STAS1;  Q3K1Q7, NAGB_STRA1;  
P65514, NAGB_STRA3;  P65515, NAGB_STRA5;  P59689, NAGB_STRAW;  
Q9K487, NAGB_STRCO;  C0M970, NAGB_STRE4;  B4U206, NAGB_STREM;  
A8AYK4, NAGB_STRGC;  Q8DV70, NAGB_STRMU;  Q99Z50, NAGB_STRP1;  
Q04JT5, NAGB_STRP2;  P0DC66, NAGB_STRP3;  B5E5S3, NAGB_STRP4;  
Q5XBG4, NAGB_STRP6;  C1C814, NAGB_STRP7;  Q8P0E0, NAGB_STRP8;  
A2RDX6, NAGB_STRPG;  B1ICL5, NAGB_STRPI;  B8ZKX4, NAGB_STRPJ;  
Q97Q16, NAGB_STRPN;  P0DC67, NAGB_STRPQ;  B5XM45, NAGB_STRPZ;  
Q8DPA1, NAGB_STRR6;  A4W0A3, NAGB_STRS2;  C0MCU1, NAGB_STRS7;  
A3CLX4, NAGB_STRSV;  A4VU11, NAGB_STRSY;  Q03LS1, NAGB_STRTD;  
B9DWG4, NAGB_STRU0;  C1CF03, NAGB_STRZJ;  C1CLC3, NAGB_STRZP;  
C1CQU2, NAGB_STRZT;  B0K934, NAGB_THEP3;  B0K0J7, NAGB_THEPX;  
C4L889, NAGB_TOLAT;  Q73QV6, NAGB_TREDE;  A5F125, NAGB_VIBC3;  
A7N5W3, NAGB_VIBCB;  Q9KKS5, NAGB_VIBCH;  C3LWT7, NAGB_VIBCM;  
Q5E294, NAGB_VIBF1;  B5FBU7, NAGB_VIBFM;  Q87K60, NAGB_VIBPA;  
B7VTI0, NAGB_VIBTL;  Q8D4T9, NAGB_VIBVU;  Q7MGE1, NAGB_VIBVY;  
A1JQE8, NAGB_YERE8;  A7FKU3, NAGB_YERP3;  Q1C537, NAGB_YERPA;  
B2K8A2, NAGB_YERPB;  Q8ZDE1, NAGB_YERPE;  A9R7S4, NAGB_YERPG;  
Q1CKN7, NAGB_YERPN;  A4TNY0, NAGB_YERPP;  Q66DC7, NAGB_YERPS;  
B1JG88, NAGB_YERPY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.99.-
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