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ENZYME entry: EC 3.5.99.7

Accepted Name
1-aminocyclopropane-1-carboxylate deaminase.
Alternative Name(s)
1-aminocyclopropane carboxylic acid deaminase.
1-aminocyclopropane-1-carboxylate endolyase (deaminating).
ACC deaminase.
Reaction catalysed
1-aminocyclopropane-1-carboxylate + H(2)O <=> 2-oxobutanoate + NH(3)
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme, found in certain soil bacteria and fungi, catalyzes the ring opening of 1-aminocyclopropane-1-carboxylate, the immediate precursor to ethylene, an important plant hormone that regulates fruit ripening and other processes.
  • The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes spontaneous hydrolytic deamination.
  • The enzyme has been used to make fruit ripening dependent on externally added ethylene, as it removes the substrate for endogenous ethylene formation.
  • Formerly EC 4.1.99.4.
Cross-references
BRENDA3.5.99.7
EC2PDB3.5.99.7
ExplorEnz3.5.99.7
PRIAM enzyme-specific profiles3.5.99.7
KEGG Ligand Database for Enzyme Nomenclature3.5.99.7
IUBMB Enzyme Nomenclature3.5.99.7
IntEnz3.5.99.7
MEDLINEFind literature relating to 3.5.99.7
MetaCyc3.5.99.7
UniProtKB/Swiss-Prot
A1TVP2, 1A1D_ACIAC;  B9MGI8, 1A1D_ACIET;  B9JJB7, 1A1D_AGRRK;  
B9K206, 1A1D_AGRVS;  Q89XR6, 1A1D_BRADU;  A5EJ46, 1A1D_BRASB;  
A4YUJ5, 1A1D_BRASO;  B1YYR8, 1A1D_BURA4;  Q1BL32, 1A1D_BURCA;  
B1K774, 1A1D_BURCC;  A0AXI7, 1A1D_BURCH;  B4EJA6, 1A1D_BURCJ;  
Q0B569, 1A1D_BURCM;  A9AQJ3, 1A1D_BURM1;  A3ME84, 1A1D_BURM7;  
A2RWH4, 1A1D_BURM9;  Q62CE3, 1A1D_BURMA;  A1UVN3, 1A1D_BURMS;  
A3P669, 1A1D_BURP0;  Q3JLQ0, 1A1D_BURP1;  A3NKK4, 1A1D_BURP6;  
B2TBV3, 1A1D_BURPP;  Q63KN7, 1A1D_BURPS;  Q390Z5, 1A1D_BURS3;  
Q2T6A1, 1A1D_BURTA;  A4JKV8, 1A1D_BURVG;  Q13ME5, 1A1D_BURXL;  
Q5KMX3, 1A1D_CRYNJ;  Q0K1H0, 1A1D_CUPNH;  Q7M523, 1A1D_CYBSA;  
Q9ZHW3, 1A1D_ENTCL;  B8IP05, 1A1D_METNO;  A2SLW2, 1A1D_METPP;  
B0UGM0, 1A1D_METS4;  Q48KS9, 1A1D_PSE14;  Q51813, 1A1D_PSEFL;  
Q5PWZ8, 1A1D_PSEPU;  P30297, 1A1D_PSES0;  Q87YW7, 1A1D_PSESM;  
Q4ZVH4, 1A1D_PSEU2;  Q00740, 1A1D_PSEUD;  Q9V2L2, 1A1D_PYRAB;  
Q8U4R3, 1A1D_PYRFU;  O57809, 1A1D_PYRHO;  B2UGM5, 1A1D_RALPJ;  
Q8XS35, 1A1D_RALSO;  Q98AM7, 1A1D_RHILO;  Q93AG0, 1A1D_RHILV;  
Q9AHF0, 1A1D_RHIRD;  Q9URX3, 1A1D_SCHPO;  Q9WY68, 1A1D_THEMA;  
Q6J256, 1A1D_VARPD;  C5CQC9, 1A1D_VARPS;  F4HYF3, DCYD1_ARATH;  

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