ENZYME entry: EC 3.6.1.15

Accepted Name
Nucleoside-triphosphate phosphatase.
Alternative Name(s)
NTPase.
Nucleoside 5-triphosphatase.
Nucleoside triphosphate hydrolase.
Nucleoside triphosphate phosphohydrolase.
Nucleoside-5-triphosphate phosphohydrolase.
Nucleoside-triphosphatase.
Reaction catalysed
NTP + H(2)O <=> NDP + phosphate
Comment(s)
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
Cross-references
PROSITEPDOC00952
BRENDA3.6.1.15
EC2PDB3.6.1.15
ExplorEnz3.6.1.15
PRIAM enzyme-specific profiles3.6.1.15
KEGG Ligand Database for Enzyme Nomenclature3.6.1.15
IUBMB Enzyme Nomenclature3.6.1.15
IntEnz3.6.1.15
MEDLINEFind literature relating to 3.6.1.15
MetaCyc3.6.1.15
UniProtKB/Swiss-Prot
P29814, NTP1_AMEPV;  Q18411, NTP1_CAEEL;  P24486, NTP1_CBEPV;  
O91729, NTP1_CFEPV;  O72907, NTP1_FOWPN;  O37319, NTP1_HAEPV;  
Q98267, NTP1_MCV1;  Q9YW39, NTP1_MSEPV;  Q9Q8L4, NTP1_MYXVL;  
Q9Q8Z2, NTP1_RFVKA;  Q08513, NTP1_SWPVK;  Q27893, NTP1_TOXGO;  
O57214, NTP1_VACCA;  P20637, NTP1_VACCC;  P05807, NTP1_VACCW;  
P33066, NTP1_VAR67;  Q9QB93, NTP1_YMTV5;  Q27895, NTP2_TOXGO;  
P52913, NTP4_TOXGO;  P52914, NTPA_PEA;  Q1LZ78, NTPCR_BOVIN;  
Q9BSD7, NTPCR_HUMAN;  Q9CQA9, NTPCR_MOUSE;  Q9YDY8, NTPTH_AERPE;  
O67322, NTPTH_AQUAE;  O29444, NTPTH_ARCFU;  A8MB70, NTPTH_CALMQ;  
A2BL86, NTPTH_HYPBU;  A8ABE2, NTPTH_IGNH4;  B1L726, NTPTH_KORCO;  
Q8TKK3, NTPTH_METAC;  Q467J7, NTPTH_METBF;  Q58954, NTPTH_METJA;  
Q8TX49, NTPTH_METKA;  A4YEP4, NTPTH_METS5;  O27140, NTPTH_METTH;  
B2A6V4, NTPTH_NATTJ;  Q6L2J8, NTPTH_PICTO;  Q9UZ81, NTPTH_PYRAB;  
Q8ZTE6, NTPTH_PYRAE;  A4WLK1, NTPTH_PYRAR;  A3MX10, NTPTH_PYRCJ;  
Q8TH18, NTPTH_PYRFU;  O58522, NTPTH_PYRHO;  A1RRZ4, NTPTH_PYRIL;  
B1Y9N2, NTPTH_PYRNV;  A3DNY5, NTPTH_STAMF;  Q4JCN8, NTPTH_SULAC;  
Q97WP0, NTPTH_SULSO;  Q96YL7, NTPTH_SULTO;  Q9HJH0, NTPTH_THEAC;  
Q5JF42, NTPTH_THEKO;  Q9WXP3, NTPTH_THEMA;  A5IL32, NTPTH_THEP1;  
A1RYX5, NTPTH_THEPD;  B1LAB2, NTPTH_THESQ;  Q97AR1, NTPTH_THEVO;  
P11125, P4_BPPH6;  Q9YLS4, POLG_AEVCA;  Q6WQ42, POLG_AEVL2;  
Q6R325, POLG_AEVVR;  Q288N7, POLG_BECN1;  Q8JN60, POLG_BECNB;  
P12915, POLG_BOVEV;  Q96662, POLG_BVDVC;  P19711, POLG_BVDVN;  
Q01499, POLG_BVDVS;  Q8V736, POLG_CACV4;  P19712, POLG_CSFVA;  
P21530, POLG_CSFVB;  Q65900, POLG_CX16G;  Q9QF31, POLG_CX16T;  
P22055, POLG_CXA21;  P36290, POLG_CXA24;  P21404, POLG_CXA9;  
P08291, POLG_CXB1J;  Q9YLG5, POLG_CXB2O;  P03313, POLG_CXB3N;  
Q66282, POLG_CXB3W;  Q86887, POLG_CXB4E;  P08292, POLG_CXB4J;  
Q03053, POLG_CXB5P;  Q9QL88, POLG_CXB6S;  P27909, POLG_DEN1B;  
P33478, POLG_DEN1S;  P17763, POLG_DEN1W;  P29990, POLG_DEN26;  
P29991, POLG_DEN27;  P14337, POLG_DEN28;  P07564, POLG_DEN2J;  
P14340, POLG_DEN2N;  P12823, POLG_DEN2P;  Q9WDA6, POLG_DEN2Q;  
P27914, POLG_DEN2T;  Q99D35, POLG_DEN3C;  Q5UB51, POLG_DEN3I;  
Q6YMS3, POLG_DEN3M;  P27915, POLG_DEN3P;  Q6YMS4, POLG_DEN3S;  
P09866, POLG_DEN4D;  Q2YHF2, POLG_DEN4H;  Q58HT7, POLG_DEN4P;  
Q5UCB8, POLG_DEN4S;  Q2YHF0, POLG_DEN4T;  Q96725, POLG_EBHSG;  
O91734, POLG_EC01F;  Q9YLJ1, POLG_EC05N;  Q66474, POLG_EC06C;  
Q66577, POLG_EC09B;  Q66849, POLG_EC09H;  P29813, POLG_EC11G;  
Q66575, POLG_EC12T;  Q9WN78, POLG_EC30B;  P03304, POLG_EMCV;  
P17593, POLG_EMCVB;  P17594, POLG_EMCVD;  Q66765, POLG_EMCVR;  
P12296, POLG_ENMGO;  P27407, POLG_FCVC6;  P27408, POLG_FCVF4;  
P27409, POLG_FCVF9;  Q66914, POLG_FCVUR;  P03306, POLG_FMDV1;  
P03307, POLG_FMDV5;  P03308, POLG_FMDVA;  P03309, POLG_FMDVC;  
P03310, POLG_FMDVI;  P03305, POLG_FMDVO;  P03311, POLG_FMDVS;  
P49303, POLG_FMDVZ;  Q69422, POLG_GBVB;  Q8V0N6, POLG_HAV88;  
Q5Y944, POLG_HAVCF;  Q67825, POLG_HAVGB;  A3FMB2, POLG_HAVH2;  
Q05794, POLG_HAVHA;  P08617, POLG_HAVHM;  A5LGW7, POLG_HAVJ8;  
P06441, POLG_HAVLA;  P13901, POLG_HAVMB;  Q9DWR1, POLG_HAVNO;  
P14553, POLG_HAVS2;  P26664, POLG_HCV1;  Q5I2N3, POLG_HCV6A;  
Q68749, POLG_HCVBB;  P26663, POLG_HCVBK;  Q9WMX2, POLG_HCVCO;  
O39929, POLG_HCVED;  O39927, POLG_HCVEU;  O39928, POLG_HCVEV;  
P27958, POLG_HCVH;  Q81754, POLG_HCVH9;  Q913D4, POLG_HCVIN;  
Q03463, POLG_HCVJ1;  O92972, POLG_HCVJ4;  P26660, POLG_HCVJ6;  
P26661, POLG_HCVJ8;  P26662, POLG_HCVJA;  Q99IB8, POLG_HCVJF;  
Q68801, POLG_HCVJK;  Q68798, POLG_HCVJL;  Q9DHD6, POLG_HCVJP;  
Q00269, POLG_HCVJT;  Q81495, POLG_HCVK3;  Q81258, POLG_HCVNZ;  
Q913V3, POLG_HCVR6;  O91936, POLG_HCVSA;  O92529, POLG_HCVT5;  
Q81487, POLG_HCVTR;  P29846, POLG_HCVTW;  Q9QAX1, POLG_HCVVA;  
O92530, POLG_HCVVN;  O92531, POLG_HCVVO;  O92532, POLG_HCVVP;  
P32537, POLG_HE701;  Q66478, POLG_HE71B;  Q66479, POLG_HE71M;  
Q66578, POLG_HPE1H;  Q9YID8, POLG_HPE23;  O73556, POLG_HPE2W;  
P03303, POLG_HRV14;  Q82122, POLG_HRV16;  P23008, POLG_HRV1A;  
P12916, POLG_HRV1B;  P04936, POLG_HRV2;  Q82081, POLG_HRV3;  
P07210, POLG_HRV8A;  P27395, POLG_JAEV1;  P19110, POLG_JAEV5;  
P32886, POLG_JAEVJ;  P14403, POLG_JAEVN;  P14335, POLG_KUNJM;  
P29837, POLG_LANVT;  P22338, POLG_LIV;  P54634, POLG_LORDV;  
P33515, POLG_MCFA;  P05769, POLG_MVEV5;  Q83883, POLG_NVN68;  
Q9QEJ5, POLG_PESV;  O41174, POLG_PEV9U;  P03300, POLG_POL1M;  
P03301, POLG_POL1S;  P06210, POLG_POL2L;  P23069, POLG_POL2W;  
P06209, POLG_POL32;  P03302, POLG_POL3L;  Q04538, POLG_POWVL;  
P27411, POLG_RHDV3;  Q86119, POLG_RHDVA;  Q89273, POLG_RHDVB;  
P27410, POLG_RHDVF;  Q86117, POLG_RHDVS;  P36286, POLG_SMSV1;  
P36287, POLG_SMSV4;  Q04544, POLG_SOUV3;  P09732, POLG_STEVM;  
P16604, POLG_SVDVH;  P13900, POLG_SVDVU;  Q6XDK8, POLG_SVM10;  
Q69014, POLG_SVM93;  Q672I1, POLG_SVSAP;  Q01299, POLG_TBEVH;  
P07720, POLG_TBEVS;  P14336, POLG_TBEVW;  P08544, POLG_TMEVB;  
P13899, POLG_TMEVD;  P08545, POLG_TMEVG;  Q9DUN3, POLG_VESVA;  
P06935, POLG_WNV;  P03314, POLG_YEFV1;  Q6DV88, POLG_YEFVA;  
Q6J3P1, POLG_YEFVC;  Q074N0, POLG_YEFVE;  Q89277, POLG_YEFVF;  
Q98803, POLG_YEFVI;  Q1X881, POLG_YEFVN;  Q9YRV3, POLG_YEFVT;  
Q1X880, POLG_YEFVU;  Q32ZE1, POLG_ZIKV;  Q86924, POLN_AURAV;  
P87515, POLN_BFV;  Q5XXP4, POLN_CHIK3;  Q8JUX6, POLN_CHIKS;  
Q306W6, POLN_EEEV1;  Q306W8, POLN_EEEV8;  Q4QXJ8, POLN_EEEVF;  
P36327, POLN_EEVV3;  Q8V294, POLN_EEVVC;  Q9WJC7, POLN_EEVVM;  
P36328, POLN_EEVVP;  P27282, POLN_EEVVT;  Q5Y389, POLN_GETV;  
Q8QZ73, POLN_MAYAB;  P13886, POLN_ONNVG;  O90370, POLN_ONNVI;  
O90368, POLN_ONNVS;  P13887, POLN_RRVN;  Q6X2U4, POLN_RUBVB;  
Q6X2U2, POLN_RUBVC;  Q9J6K9, POLN_RUBVD;  Q86500, POLN_RUBVM;  
Q8BCR0, POLN_RUBVN;  Q99IE7, POLN_RUBVO;  O40955, POLN_RUBVR;  
P13889, POLN_RUBVT;  Q99IE5, POLN_RUBVV;  Q9JGL0, POLN_SAGV;  
P08411, POLN_SFV;  P27283, POLN_SINDO;  P03317, POLN_SINDV;  
Q8QL53, POLN_SLDV;  Q8JJX1, POLN_SPDV;  P13896, POLN_WEEV;  

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