ENZYME entry: EC 3.6.1.17

Accepted Name
Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical).
Alternative Name(s)
Ap(4)A hydrolase.
Ap(4)Aase.
Ap4A hydrolase.
Ap4Aase.
Bis(5'-adenosyl)-tetraphosphatase.
Bis(5'-guanosyl)-tetraphosphatase.
Diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase.
Diadenosinetetraphosphatase (asymmetrical).
Diguanosinetetraphosphatase (asymmetrical).
Dinucleosidetetraphosphatase (asymmetrical).
Reaction catalysed
P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O <=> GTP + GMP
Comment(s)
Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate (cf. EC 3.6.1.41).
Cross-references
PROSITEPDOC00694 ; PDOC00695
BRENDA3.6.1.17
EC2PDB3.6.1.17
ExplorEnz3.6.1.17
PRIAM enzyme-specific profiles3.6.1.17
KEGG Ligand Database for Enzyme Nomenclature3.6.1.17
IUBMB Enzyme Nomenclature3.6.1.17
IntEnz3.6.1.17
MEDLINEFind literature relating to 3.6.1.17
MetaCyc3.6.1.17
UniProtKB/Swiss-Prot
Q29RJ1, AP4A_BOVIN;  P50583, AP4A_HUMAN;  P56380, AP4A_MOUSE;  
P50584, AP4A_PIG;  Q6PEC0, AP4A_RAT;  P49776, APH1_SCHPO;  
Q9C6Z2, NUD25_ARATH;  B7GLK2, PRPE_ANOFW;  C3P3Q5, PRPE_BACAA;  
C3LBR5, PRPE_BACAC;  A0RB32, PRPE_BACAH;  Q81TQ0, PRPE_BACAN;  
B7JEP5, PRPE_BACC0;  Q73BU4, PRPE_BACC1;  B7ILE8, PRPE_BACC2;  
C1ELB5, PRPE_BACC3;  B7HGW3, PRPE_BACC4;  B7I0B6, PRPE_BACC7;  
A7GM94, PRPE_BACCN;  B9IU03, PRPE_BACCQ;  Q81GJ7, PRPE_BACCR;  
Q63EG2, PRPE_BACCZ;  Q9K907, PRPE_BACHD;  Q6HLX9, PRPE_BACHK;  
Q65LA0, PRPE_BACLD;  A7Z3F2, PRPE_BACMF;  O31614, PRPE_BACSU;  
A9VJS5, PRPE_BACWK;  Q5L1R3, PRPE_GEOKA;  C5D7A6, PRPE_GEOSW;  
A4IL88, PRPE_GEOTN;  Q8ERS7, PRPE_OCEIH;  

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