ENZYME entry: EC 3.6.1.40

Accepted Name
Guanosine-5'-triphosphate,3'-diphosphate diphosphatase.
Alternative Name(s)
Guanosine pentaphosphate phosphohydrolase.
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase.
pppGpp 5'-phosphohydrolase.
Reaction catalysed
Guanosine 5'-triphosphate,3'-diphosphate + H(2)O <=> guanosine 3',5'-bis(diphosphate) + phosphate
Comment(s)
Also hydrolyzes other guanosine 5'-triphosphate derivatives with at least one unsubstituted phosphate group on the 3'-position, but not GTP, ATP or adenosine 5'-triphosphate,3'-diphosphate.
Cross-references
BRENDA3.6.1.40
EC2PDB3.6.1.40
ExplorEnz3.6.1.40
PRIAM enzyme-specific profiles3.6.1.40
KEGG Ligand Database for Enzyme Nomenclature3.6.1.40
IUBMB Enzyme Nomenclature3.6.1.40
IntEnz3.6.1.40
MEDLINEFind literature relating to 3.6.1.40
MetaCyc3.6.1.40
UniProtKB/Swiss-Prot
A0KEG8, GPPA_AERHH;  A4STJ8, GPPA_AERS4;  A8ACT2, GPPA_CITK8;  
A7MQI3, GPPA_CROS8;  A7ZTY0, GPPA_ECO24;  B7UMN4, GPPA_ECO27;  
B7MGI9, GPPA_ECO45;  B7L8C0, GPPA_ECO55;  Q8XAT5, GPPA_ECO57;  
B5YY27, GPPA_ECO5E;  B7NTG3, GPPA_ECO7I;  B7N272, GPPA_ECO81;  
B7M5C6, GPPA_ECO8A;  C4ZZ47, GPPA_ECOBW;  B1X9Z3, GPPA_ECODH;  
A8A6N3, GPPA_ECOHS;  A1AHU9, GPPA_ECOK1;  Q8FBR0, GPPA_ECOL6;  
B1IWC1, GPPA_ECOLC;  P25552, GPPA_ECOLI;  B7NF84, GPPA_ECOLU;  
B6I4B5, GPPA_ECOSE;  B1LLV2, GPPA_ECOSM;  Q1R4G0, GPPA_ECOUT;  
A4WG31, GPPA_ENT38;  B2VG72, GPPA_ERWT9;  B7LU76, GPPA_ESCF3;  
B5XYZ0, GPPA_KLEP3;  A6TGG8, GPPA_KLEP7;  Q6CZD8, GPPA_PECAS;  
C6DHF6, GPPA_PECCP;  Q7MYL1, GPPA_PHOLL;  Q6LLL4, GPPA_PHOPR;  
B4F1V2, GPPA_PROMH;  Q15N19, GPPA_PSEA6;  Q3IDD5, GPPA_PSEHT;  
B5EZ39, GPPA_SALA4;  A9MJ30, GPPA_SALAR;  Q57HT7, GPPA_SALCH;  
B5FN73, GPPA_SALDC;  B5QVH1, GPPA_SALEP;  B5RFS4, GPPA_SALG2;  
B4TB12, GPPA_SALHS;  B4SZ25, GPPA_SALNS;  Q5PKK4, GPPA_SALPA;  
A9MXF2, GPPA_SALPB;  C0Q2V8, GPPA_SALPC;  B5BIS8, GPPA_SALPK;  
B4TNT2, GPPA_SALSV;  P0A268, GPPA_SALTI;  P0A267, GPPA_SALTY;  
A8G827, GPPA_SERP5;  B2TU13, GPPA_SHIB3;  Q31UK6, GPPA_SHIBS;  
Q329V7, GPPA_SHIDS;  Q0SYW9, GPPA_SHIF8;  Q83PI3, GPPA_SHIFL;  
Q3YVI5, GPPA_SHISS;  Q2NQB1, GPPA_SODGM;  A5F3R3, GPPA_VIBC3;  
A7MXT2, GPPA_VIBCB;  Q9KV53, GPPA_VIBCH;  C3LQR0, GPPA_VIBCM;  
Q5E8U7, GPPA_VIBF1;  B5FF86, GPPA_VIBFM;  Q87KH4, GPPA_VIBPA;  
B7VMF0, GPPA_VIBTL;  Q8DDN5, GPPA_VIBVU;  Q7MGP6, GPPA_VIBVY;  
A1JI66, GPPA_YERE8;  A7FD46, GPPA_YERP3;  B2K045, GPPA_YERPB;  
Q74R94, GPPA_YERPE;  A9R8H6, GPPA_YERPG;  A4TRC9, GPPA_YERPP;  
Q66G20, GPPA_YERPS;  B1JQ12, GPPA_YERPY;  

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