ENZYME entry: EC 3.6.1.55
| Accepted Name |
|---|
| 8-oxo-dGTP diphosphatase.
|
| Alternative Name(s) |
|---|
| 7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase. |
| 7,8-dihydro-8-oxoguanine triphosphatase. |
| 8-oxo-dGTPase. |
| Reaction catalysed |
|---|
| 8-oxo-dGTP + H(2)O <=> 8-oxo-dGMP + diphosphate |
| Cofactor(s) |
|---|
| Magnesium.
|
| Comment(s) |
|---|
- This enzyme hydrolyzes the phosphoanhydride bond between the alpha
and beta phosphate of 8-oxoguanine-containing nucleoside di- and
triphosphates thereby preventing misincorporation of the oxidized
purine nucleoside triphosphates into DNA.
- It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).
|
| Cross-references |
|---|
| BRENDA | 3.6.1.55 |
| EC2PDB | 3.6.1.55 |
| ExplorEnz | 3.6.1.55 |
| PRIAM enzyme-specific profiles | 3.6.1.55 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.6.1.55 |
| IUBMB Enzyme Nomenclature | 3.6.1.55 |
| IntEnz | 3.6.1.55 |
| MEDLINE | Find literature relating to 3.6.1.55 |
| MetaCyc | 3.6.1.55 |
| UniProtKB/Swiss-Prot |
| P36639, 8ODP_HUMAN; | P53368, 8ODP_MOUSE; | P53369, 8ODP_RAT; |
| P95110, MUTT1_MYCTU; | O06558, MUTT2_MYCTU; | P96259, MUTT3_MYCTU; |
| P96590, MUTT_BACSU; | P57298, MUTT_BUCAI; | Q8K9U2, MUTT_BUCAP; |
| P08337, MUTT_ECOLI; | P44932, MUTT_HAEIN; | P32090, MUTT_PROVU; |
| P95781, MUTX_STRMU; | P41354, MUTX_STRPN; | P59659, MUTX_STRR6; |
| Q9NV35, NUD15_HUMAN; | Q8BG93, NUD15_MOUSE; | Q9CA40, NUDT1_ARATH; |
| Q12524, PCD1_YEAST; | O35013, YTKD_BACSU; |
|
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