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ENZYME entry: EC

Accepted Name
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
Alternative Name(s)
M(7)GpppN m(7)GMP phosphohydrolase.
M(7)GpppX diphosphatase.
M(7)GpppX pyrophosphatase.
Reaction catalysed
A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O <=> N(7)-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]
  • The enzyme removes (decaps) the N(7)-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides.
  • Decapping is an important process in the control of eukaryotic mRNA degradation.
  • The enzyme functions to clear the cell of cap structure following decay of the RNA body.
  • The nematode enzyme can also decap triply methylated substrates, 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-[mRNA].
  • Formerly EC
PRIAM enzyme-specific profiles3.6.1.59
KEGG Ligand Database for Enzyme Nomenclature3.6.1.59
IUBMB Enzyme Nomenclature3.6.1.59
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