ENZYME entry: EC 3.6.1.59

Accepted Name
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
Alternative Name(s)
M(7)GpppN m(7)GMP phosphohydrolase.
M(7)GpppX diphosphatase.
M(7)GpppX pyrophosphatase.
Reaction catalysed
A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O <=> N(7)-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]
Comment(s)
  • The enzyme removes (decaps) the N(7)-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides.
  • Decapping is an important process in the control of eukaryotic mRNA degradation.
  • The enzyme functions to clear the cell of cap structure following decay of the RNA body.
  • The nematode enzyme can also decap triply methylated substrates, 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-[mRNA].
  • Formerly EC 3.6.1.30.
Cross-references
BRENDA3.6.1.59
EC2PDB3.6.1.59
ExplorEnz3.6.1.59
PRIAM enzyme-specific profiles3.6.1.59
KEGG Ligand Database for Enzyme Nomenclature3.6.1.59
IUBMB Enzyme Nomenclature3.6.1.59
IntEnz3.6.1.59
MEDLINEFind literature relating to 3.6.1.59
MetaCyc3.6.1.59
UniProtKB/Swiss-Prot
D3K0N9, DCPS_ASCSU;  Q8MJJ7, DCPS_BOVIN;  G5EFS4, DCPS_CAEEL;  
Q96C86, DCPS_HUMAN;  Q9DAR7, DCPS_MOUSE;  Q8MIZ3, DCPS_PIG;  
Q8K4F7, DCPS_RAT;  Q9P7C9, DCPS_SCHPO;  Q06151, DCPS_YEAST;  

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