ENZYME entry: EC 3.6.1.59

Accepted Name
M(7)GpppX diphosphatase.
Alternative Name(s)
M(7)GpppN m(7)GMP phosphohydrolase.
M(7)GpppX pyrophosphatase.
Reaction catalysed
  • M(7)G5'ppp5'N(3'ppp5'N)(n) + H(2)O <=> 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)(n)
  • 7-methylguanosine 5'-diphosphate + H(2)O <=> 7-methylguanosine 5'-phosphate + phosphate
Comment(s)
  • Decapping is an important process in the control of eukaryotic mRNA degradation.
  • m(7)GpppX diphosphatase functions to clear the cell of cap structure following decay of the RNA body.
  • m(7)GpppX diphosphatase is capable of acting on an mRNA once it is degraded down to 10 nucleotides, designated in reaction (1) as m(7)G5'ppp5'N(3'ppp5'N)(n) (n = 1-8).
  • Formerly EC 3.6.1.30.
Cross-references
BRENDA3.6.1.59
EC2PDB3.6.1.59
ExplorEnz3.6.1.59
PRIAM enzyme-specific profiles3.6.1.59
KEGG Ligand Database for Enzyme Nomenclature3.6.1.59
IUBMB Enzyme Nomenclature3.6.1.59
IntEnz3.6.1.59
MEDLINEFind literature relating to 3.6.1.59
MetaCyc3.6.1.59
UniProtKB/Swiss-Prot
D3K0N9, DCPS_ASCSU;  Q8MJJ7, DCPS_BOVIN;  G5EFS4, DCPS_CAEEL;  
Q96C86, DCPS_HUMAN;  Q9DAR7, DCPS_MOUSE;  Q8MIZ3, DCPS_PIG;  
Q8K4F7, DCPS_RAT;  Q9P7C9, DCPS_SCHPO;  Q06151, DCPS_YEAST;  

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