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ENZYME entry: EC 18.104.22.168
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|5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
|M(7)GpppN m(7)GMP phosphohydrolase.|
|A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O <=> N(7)-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]|
- The enzyme removes (decaps) the N(7)-methylguanosine 5-phosphate cap
from an mRNA degraded to a maximal length of 10 nucleotides.
- Decapping is an important process in the control of eukaryotic mRNA
- The enzyme functions to clear the cell of cap structure following
decay of the RNA body.
- The nematode enzyme can also decap triply methylated substrates,
- Formerly EC 22.214.171.124.
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
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