To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 3.6.1.5

Accepted Name
Apyrase.
Alternative Name(s)
Adenosine diphosphatase.
ADPase.
ATP-diphosphatase.
ATP-diphosphohydrolase.
Reaction catalysed
A nucleoside 5'-triphosphate + 2 H(2)O <=> a nucleoside 5'-phosphate + 2 phosphate
Cofactor(s)
Ca(2+).
Comment(s)
  • Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates.
  • They differ from ATPases, which specifically hydrolyze ATP, by hydrolyzing both ATP and ADP.
  • Most of the ecto-ATPases that occur on the cell surface and hydrolyze extracellular nucleotides belong to this enzyme family.
Cross-references
PROSITEPDOC00952
BRENDA3.6.1.5
EC2PDB3.6.1.5
ExplorEnz3.6.1.5
PRIAM enzyme-specific profiles3.6.1.5
KEGG Ligand Database for Enzyme Nomenclature3.6.1.5
IUBMB Enzyme Nomenclature3.6.1.5
IntEnz3.6.1.5
MEDLINEFind literature relating to 3.6.1.5
MetaCyc3.6.1.5
UniProtKB/Swiss-Prot
Q9SQG2, APY1_ARATH;  Q8H7L6, APY1_ORYSJ;  Q9SPM5, APY2_ARATH;  
Q6Z4P2, APY2_ORYSJ;  Q9XI62, APY3_ARATH;  Q2QYE1, APY3_ORYSJ;  
Q8H1D8, APY4_ARATH;  Q6NQA8, APY5_ARATH;  O80612, APY6_ARATH;  
F4JSH1, APY7_ARATH;  P50635, APY_AEDAE;  E0D877, APY_AEDAL;  
O96559, APY_CIMLE;  P80595, APY_SOLTU;  B3A0N5, APY_TABYA;  
O18956, ENTP1_BOVIN;  P49961, ENTP1_HUMAN;  P55772, ENTP1_MOUSE;  
Q9MYU4, ENTP1_PIG;  P97687, ENTP1_RAT;  O75355, ENTP3_HUMAN;  
A0JND9, ENTP8_BOVIN;  O93295, ENTP8_CHICK;  Q5MY95, ENTP8_HUMAN;  
Q8K0L2, ENTP8_MOUSE;  Q5DRK1, ENTP8_RAT;  Q9USP2, YND1_SCHPO;  
P40009, YND1_YEAST;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-