ID   3.6.1.60
DE   diadenosine hexaphosphate hydrolase (AMP-forming).
CA   (1) H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine
CA   5'-pentaphosphate + AMP + 2 H(+).
CA   (2) H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = adenosine
CA   5'-tetraphosphate + AMP + 2 H(+).
CC   -!- A divalent cation is essential for activity.
CC   -!- Mn(2+) (2-6 mM) is most effective.
CC   -!- The enzyme controls intracellular levels of P(1),P(5)-
CC       bis(5'-adenosyl)pentaphosphate and P(1),P(6)-
CC       bis(5'-adenosyl)hexaphosphate.
CC   -!- Weak activity with P(1),P(4)-bis(5'-adenosyl)tetraphosphate.
CC   -!- Marked preference for adenine over guanine nucleotides.
DR   Q99321, DDP1_YEAST ;  Q8NFP7, NUD10_HUMAN;  P0C027, NUD10_MOUSE;
DR   Q58CW0, NUD11_BOVIN;  Q96G61, NUD11_HUMAN;  P0C028, NUD11_MOUSE;
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