ID   3.6.1.62
DE   5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
AN   m(7)GpppN-mRNA hydrolase.
CA   a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA +
CA   H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.
CC   -!- Decapping of mRNA is a critical step in eukaryotic mRNA turnover.
CC   -!- The enzyme is unable to cleave a free cap structure (m(7)GpppG).
CC   -!- The enzyme from Vaccinia virus is synergistically activated in the
CC       presence of Mg(2+) and Mn(2+).
CC   -!- Formerly EC 3.6.1.30.
DR   Q9NPI6, DCP1A_HUMAN;  Q91YD3, DCP1A_MOUSE;  I3LHS8, DCP1A_PIG  ;
DR   Q3SZL6, DCP1B_BOVIN;  Q8IZD4, DCP1B_HUMAN;  Q3U564, DCP1B_MOUSE;
DR   Q5R413, DCP1B_PONAB;  Q8GW31, DCP2_ARATH ;  O62255, DCP2_CAEEL ;
DR   Q8IU60, DCP2_HUMAN ;  Q9CYC6, DCP2_MOUSE ;  Q5REQ8, DCP2_PONAB ;
DR   P53550, DCP2_YEAST ;  A1A4Q9, NUD16_BOVIN;  P0DKY8, NUD16_HOMVI;
DR   Q96DE0, NUD16_HUMAN;  Q6P3D0, NUD16_MOUSE;  Q2V8X7, NUD16_SHEEP;
DR   Q6TEC1, NUD16_XENLA;  A2VE79, NUDT3_BOVIN;  O95989, NUDT3_HUMAN;
DR   Q9JI46, NUDT3_MOUSE;  Q566C7, NUDT3_RAT  ;
//