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ENZYME entry: EC 3.6.1.9

Accepted Name
Nucleotide diphosphatase.
Alternative Name(s)
Dinucleotide nucleotidohydrolase.
Nucleoside-triphosphate diphosphatase.
Nucleotide pyrophosphatase.
Reaction catalysed
A nucleoside triphosphate + H(2)O <=> a nucleotide + diphosphate
Comment(s)
  • The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates.
  • In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA.
  • Formerly EC 3.6.1.19.
Cross-references
BRENDA3.6.1.9
EC2PDB3.6.1.9
ExplorEnz3.6.1.9
PRIAM enzyme-specific profiles3.6.1.9
KEGG Ligand Database for Enzyme Nomenclature3.6.1.9
IUBMB Enzyme Nomenclature3.6.1.9
IntEnz3.6.1.9
MEDLINEFind literature relating to 3.6.1.9
MetaCyc3.6.1.9
UniProtKB/Swiss-Prot
P22413, ENPP1_HUMAN;  P06802, ENPP1_MOUSE;  Q924C3, ENPP1_RAT;  
P15396, ENPP3_BOVIN;  O14638, ENPP3_HUMAN;  Q6DYE8, ENPP3_MOUSE;  
Q5R5M5, ENPP3_PONAB;  P97675, ENPP3_RAT;  Q4DBX5, ITPA1_TRYCC;  
Q4DRX4, ITPA2_TRYCC;  Q16YB3, ITPA_AEDAE;  C0NE84, ITPA_AJECG;  
Q7Q4F5, ITPA_ANOGA;  Q8L968, ITPA_ARATH;  Q752Z9, ITPA_ASHGO;  
Q4WTN9, ITPA_ASPFU;  Q2TX99, ITPA_ASPOR;  F4P9L8, ITPA_BATDJ;  
Q2KIC5, ITPA_BOVIN;  A8XZP2, ITPA_CAEBR;  Q9GYG4, ITPA_CAEEL;  
Q59N80, ITPA_CANAL;  C4YRQ5, ITPA_CANAW;  Q6FUV2, ITPA_CANGA;  
Q2GW61, ITPA_CHAGB;  F1NLH9, ITPA_CHICK;  F6Y089, ITPA_CIOIN;  
E3QBC5, ITPA_COLGM;  A8NZ80, ITPA_COPC7;  Q5KPF3, ITPA_CRYNJ;  
B0XL39, ITPA_CULQU;  A5WVX0, ITPA_DANRE;  Q6BIT7, ITPA_DEBHA;  
Q54LQ6, ITPA_DICDI;  Q9VMW7, ITPA_DROME;  C8V9B7, ITPA_EMENI;  
Q8SS24, ITPA_ENCCU;  E0S6S0, ITPA_ENCIT;  A8BKZ6, ITPA_GIAIC;  
Q9BY32, ITPA_HUMAN;  Q6CV82, ITPA_KLULA;  Q4Q0V1, ITPA_LEIMA;  
A4R1J6, ITPA_MAGO7;  B6TNW8, ITPA_MAIZE;  C1FI13, ITPA_MICCC;  
A9VE54, ITPA_MONBE;  Q9D892, ITPA_MOUSE;  C7YTE3, ITPA_NECH7;  
A7RWC9, ITPA_NEMVE;  Q1K4R6, ITPA_NEUCR;  B8BH95, ITPA_ORYSI;  
Q7XDP2, ITPA_ORYSJ;  E0VVF6, ITPA_PEDHC;  Q0UFP3, ITPA_PHANO;  
D0MY11, ITPA_PHYIT;  A3LVK6, ITPA_PICST;  Q8IBP3, ITPA_PLAF7;  
B2B5Q3, ITPA_PODAN;  E3KAB5, ITPA_PUCGT;  D3ZW55, ITPA_RAT;  
Q9UU89, ITPA_SCHPO;  C5WZH0, ITPA_SORBI;  D5GCI8, ITPA_TUBMM;  
Q4PD06, ITPA_USTMA;  F6HS55, ITPA_VITVI;  Q2NLA8, ITPA_XENLA;  
Q6CDL9, ITPA_YARLI;  P47119, ITPA_YEAST;  Q9X015, MAZG_THEMA;  
P25353, NPP1_YEAST;  P39997, NPP2_YEAST;  Q9NV35, NUD15_HUMAN;  
Q8BG93, NUD15_MOUSE;  A7ZP69, NUDI_ECO24;  B7UFR3, NUDI_ECO27;  
B7MG18, NUDI_ECO45;  B7LAR6, NUDI_ECO55;  Q8XE00, NUDI_ECO57;  
B7NN72, NUDI_ECO7I;  B7MXT2, NUDI_ECO81;  B7M5T3, NUDI_ECO8A;  
C4ZU93, NUDI_ECOBW;  B1X8W4, NUDI_ECODH;  A8A2B8, NUDI_ECOHS;  
A1ADA3, NUDI_ECOK1;  Q0TFJ1, NUDI_ECOL5;  Q8FFM5, NUDI_ECOL6;  
B1IXT6, NUDI_ECOLC;  P52006, NUDI_ECOLI;  B7N5L6, NUDI_ECOLU;  
B6I7J4, NUDI_ECOSE;  B1LLK5, NUDI_ECOSM;  Q1R9G4, NUDI_ECOUT;  
A4WDK7, NUDI_ENT38;  B7LM80, NUDI_ESCF3;  B5XNX5, NUDI_KLEP3;  
A6TBV3, NUDI_KLEP7;  B5EZH4, NUDI_SALA4;  A9MJC8, NUDI_SALAR;  
Q57M59, NUDI_SALCH;  B5FNT5, NUDI_SALDC;  B5R268, NUDI_SALEP;  
B5RCC0, NUDI_SALG2;  B4TBG2, NUDI_SALHS;  B4SYW7, NUDI_SALNS;  
Q5PC77, NUDI_SALPA;  A9N5B7, NUDI_SALPB;  C0Q073, NUDI_SALPC;  
B5BCQ0, NUDI_SALPK;  B4TPH8, NUDI_SALSV;  Q8Z544, NUDI_SALTI;  
Q8ZNF5, NUDI_SALTY;  Q0T2N2, NUDI_SHIF8;  Q83KB9, NUDI_SHIFL;  
Q3YZV5, NUDI_SHISS;  J3SEZ3, PDE1_CROAD;  J3SBP3, PDE2_CROAD;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-