ENZYME entry: EC 3.6.3.10

Accepted Name
Hydrogen/potassium-exchanging ATPase.
Alternative Name(s)
Gastric H(+)/K(+) ATPase.
H(+)/K(+)-ATPase.
H(+)/K(+)-exchanging ATPase.
Potassium-transporting ATPase.
Proton pump.
Reaction catalysed
ATP + H(2)O + H(+)(In) + K(+)(Out) <=> ADP + phosphate + H(+)(Out) + K(+)(In)
Cofactor(s)
Magnesium.
Comment(s)
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • Hydrolysis of ATP is coupled with the exchange of H(+) and K(+) ions.
  • Formerly EC 3.6.1.36.
Cross-references
PROSITEPDOC00139
BRENDA3.6.3.10
EC2PDB3.6.3.10
ExplorEnz3.6.3.10
PRIAM enzyme-specific profiles3.6.3.10
KEGG Ligand Database for Enzyme Nomenclature3.6.3.10
IUBMB Enzyme Nomenclature3.6.3.10
IntEnz3.6.3.10
MEDLINEFind literature relating to 3.6.3.10
MetaCyc3.6.3.10
UniProtKB/Swiss-Prot
Q92036, AT12A_BUFMA;  Q64392, AT12A_CAVPO;  P54707, AT12A_HUMAN;  
Q9Z1W8, AT12A_MOUSE;  Q9TV52, AT12A_RABIT;  P54708, AT12A_RAT;  
P50996, ATP4A_CANFA;  P20648, ATP4A_HUMAN;  Q64436, ATP4A_MOUSE;  
P19156, ATP4A_PIG;  P27112, ATP4A_RABIT;  P09626, ATP4A_RAT;  
Q92126, ATP4A_XENLA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
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