ID   3.6.3.44
DE   Xenobiotic-transporting ATPase.
AN   ATP phosphohydrolase (steroid-exporting).
AN   MDR protein.
AN   Multidrug-resistance protein.
AN   P-glycoprotein.
AN   PDR protein.
AN   Pleiotropic-drug-resistance protein.
AN   Steroid-transporting ATPase.
CA   ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
CC   -!- Enzymes of Gram-positive bacteria and eukaryotic cells that export a
CC       number of drugs, with unusual specificity, covering various groups of
CC       unrelated substances, while ignoring some that are closely related
CC       structurally.
CC   -!- Several distinct enzymes may be present in a single eukaryotic cell.
CC   -!- Many of them transport glutathione conjugates with drugs.
CC   -!- Some also show some 'flippase' (EC 3.6.3.1) activity.
CC   -!- Formerly EC 3.6.3.45.
PR   PROSITE; PDOC00185;
DR   Q9LYS2, AB10C_ARATH;  Q9C8H1, AB11C_ARATH;  Q9C8H0, AB12C_ARATH;
DR   Q9SKX0, AB13C_ARATH;  Q9LZJ5, AB14C_ARATH;  Q7FB56, AB15C_ARATH;
DR   Q9C8G9, AB1C_ARATH ;  Q42093, AB2C_ARATH ;  Q9LK64, AB3C_ARATH ;
DR   Q7DM58, AB4C_ARATH ;  Q7GB25, AB5C_ARATH ;  Q8VZZ4, AB6C_ARATH ;
DR   Q9LK62, AB7C_ARATH ;  Q8LGU1, AB8C_ARATH ;  Q9M1C7, AB9C_ARATH ;
DR   Q9P7V2, ABC4_SCHPO ;  Q9CHL8, LMRA_LACLA ;  P97046, LMRA_LACLM ;
DR   P57551, MDLA_BUCAI ;  Q8K985, MDLA_BUCAP ;  Q89A97, MDLA_BUCBP ;
DR   P77265, MDLA_ECOLI ;  P57552, MDLB_BUCAI ;  Q8K984, MDLB_BUCAP ;
DR   Q89A96, MDLB_BUCBP ;  P0AAG7, MDLB_ECO57 ;  P0AAG6, MDLB_ECOL6 ;
DR   P0AAG5, MDLB_ECOLI ;  P21447, MDR1A_MOUSE;  P06795, MDR1B_MOUSE;
DR   P21448, MDR1_CRIGR ;  P08183, MDR1_HUMAN ;  Q06034, MDR1_LEIEN ;
DR   P43245, MDR1_RAT   ;  P21449, MDR2_CRIGR ;  P23174, MDR3_CRIGR ;
DR   P21439, MDR3_HUMAN ;  P21440, MDR3_MOUSE ;  Q08201, MDR3_RAT   ;
DR   Q00449, MDR49_DROME;  Q00748, MDR65_DROME;  P21441, MDR_LEITA  ;
DR   P13568, MDR_PLAFF  ;  P34712, PGP1_CAEEL ;  P34713, PGP3_CAEEL ;
//