ENZYME entry: EC 3.6.5.1
| Accepted Name |
|---|
| Heterotrimeric G-protein GTPase.
|
| Reaction catalysed |
|---|
| GTP + H(2)O <=> GDP + phosphate |
| Comment(s) |
|---|
- This group comprises GTP-hydrolyzing systems, where GTP and GDP
alternate in binding.
- This group includes stimulatory and inhibitory G-proteins such as
G(s), G(i), G(o) and G(olf), targeting adenylate cyclase and/or K(+)
and Ca(2+) channels; G(q) stimulating phospholipase C; transducin
activating cGMP phosphodiesterase; gustducin activating cAMP
phosphodiesterase.
- G(olf) is instrumental in odor perception, transducin in vision and
gustducin in taste recognition.
- At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36
kDa) and 12 gamma subunits (6-9 kDa) are known.
- Formerly EC 3.6.1.46.
|
| Cross-references |
|---|
| PROSITE | PDOC01002 |
| BRENDA | 3.6.5.1 |
| EC2PDB | 3.6.5.1 |
| ExplorEnz | 3.6.5.1 |
| PRIAM enzyme-specific profiles | 3.6.5.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.6.5.1 |
| IUBMB Enzyme Nomenclature | 3.6.5.1 |
| IntEnz | 3.6.5.1 |
| MEDLINE | Find literature relating to 3.6.5.1 |
| MetaCyc | 3.6.5.1 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.6.5.-
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ENZYME /
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