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ENZYME entry: EC 3.7.1.12

Accepted Name
Cobalt-precorrin 5A hydrolase.
Reaction catalysed
Cobalt-precorrin-5A + H(2)O <=> cobalt-precorrin-5B + acetaldehyde + 2 H(+)
Comment(s)
  • This enzyme hydrolyzes the ring A acetate delta-lactone of cobalt- precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde.
  • This is a key reaction in the contraction of the porphyrin-type tetrapyrrole ring and its conversion to a corrin ring in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway.
Cross-references
BRENDA3.7.1.12
EC2PDB3.7.1.12
ExplorEnz3.7.1.12
PRIAM enzyme-specific profiles3.7.1.12
KEGG Ligand Database for Enzyme Nomenclature3.7.1.12
IUBMB Enzyme Nomenclature3.7.1.12
IntEnz3.7.1.12
MEDLINEFind literature relating to 3.7.1.12
MetaCyc3.7.1.12
UniProtKB/Swiss-Prot
O87697, CBIG_BACME;  Q58544, CBIG_METJA;  Q05631, CBIG_SALTY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-