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ENZYME entry: EC

Accepted Name
Phosphoribosylaminoimidazole carboxylase.
Alternative Name(s)
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase.
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase.
5-amino-1-ribosylimidazole 5-phosphate carboxylase.
5-phosphoribosyl-5-aminoimidazole carboxylase.
AIR carboxylase.
Reaction catalysed
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)
  • While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC and EC
  • 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
PRIAM enzyme-specific profiles4.1.1.21
KEGG Ligand Database for Enzyme Nomenclature4.1.1.21
IUBMB Enzyme Nomenclature4.1.1.21
MEDLINEFind literature relating to
Q10457, PUR6_CAEEL;  Q92210, PUR6_CANAL;  O74197, PUR6_CANGA;  
P38024, PUR6_CHICK;  P0CQ37, PUR6_CRYNB;  P0C017, PUR6_CRYNH;  
P0CQ36, PUR6_CRYNJ;  Q9I7S8, PUR6_DROME;  P22234, PUR6_HUMAN;  
P51583, PUR6_RAT;  P50504, PUR6_SCHOC;  P15567, PUR6_SCHPO;  
P55195, PUR6_VIGAC;  P21264, PUR6_YEAST;  Q54QE4, PURCE_DICDI;  

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