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ENZYME entry: EC 4.1.1.21

Accepted Name
Phosphoribosylaminoimidazole carboxylase.
Alternative Name(s)
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase.
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase.
5-amino-1-ribosylimidazole 5-phosphate carboxylase.
5-phosphoribosyl-5-aminoimidazole carboxylase.
AIR carboxylase.
Reaction catalysed
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)
Comment(s)
  • While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18.
  • 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
Cross-references
PROSITEPDOC50975
BRENDA4.1.1.21
EC2PDB4.1.1.21
ExplorEnz4.1.1.21
PRIAM enzyme-specific profiles4.1.1.21
KEGG Ligand Database for Enzyme Nomenclature4.1.1.21
IUBMB Enzyme Nomenclature4.1.1.21
IntEnz4.1.1.21
MEDLINEFind literature relating to 4.1.1.21
MetaCyc4.1.1.21
UniProtKB/Swiss-Prot
Q10457, PUR6_CAEEL;  Q92210, PUR6_CANAL;  O74197, PUR6_CANGA;  
P38024, PUR6_CHICK;  P0CQ37, PUR6_CRYNB;  P0C017, PUR6_CRYNH;  
P0CQ36, PUR6_CRYNJ;  Q9I7S8, PUR6_DROME;  P22234, PUR6_HUMAN;  
Q9DCL9, PUR6_MOUSE;  Q01930, PUR6_OGAME;  Q5RB59, PUR6_PONAB;  
P51583, PUR6_RAT;  P50504, PUR6_SCHOC;  P15567, PUR6_SCHPO;  
P55195, PUR6_VIGAC;  P21264, PUR6_YEAST;  Q54QE4, PURCE_DICDI;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-