ENZYME entry: EC 4.1.1.21
| Accepted Name |
|---|
| Phosphoribosylaminoimidazole carboxylase.
|
| Alternative Name(s) |
|---|
| 1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase. |
| 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase. |
| 5-amino-1-ribosylimidazole 5-phosphate carboxylase. |
| 5-phosphoribosyl-5-aminoimidazole carboxylase. |
| AIR carboxylase. |
| Reaction catalysed |
|---|
| 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2) |
| Comment(s) |
|---|
- While this is the reaction that occurs in vertebrates during purine
biosynthesis, two enzymes are required to carry out the same reaction
in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18.
- 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
|
| Cross-references |
|---|
| PROSITE | PDOC50975 |
| BRENDA | 4.1.1.21 |
| EC2PDB | 4.1.1.21 |
| ExplorEnz | 4.1.1.21 |
| PRIAM enzyme-specific profiles | 4.1.1.21 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.1.21 |
| IUBMB Enzyme Nomenclature | 4.1.1.21 |
| IntEnz | 4.1.1.21 |
| MEDLINE | Find literature relating to 4.1.1.21 |
| MetaCyc | 4.1.1.21 |
| UniProtKB/Swiss-Prot |
| Q10457, PUR6_CAEEL; | Q92210, PUR6_CANAL; | O74197, PUR6_CANGA; |
| P38024, PUR6_CHICK; | P0CQ37, PUR6_CRYNB; | P0C017, PUR6_CRYNH; |
| P0CQ36, PUR6_CRYNJ; | Q9I7S8, PUR6_DROME; | P22234, PUR6_HUMAN; |
| Q9DCL9, PUR6_MOUSE; | Q01930, PUR6_OGAME; | Q5RB59, PUR6_PONAB; |
| P51583, PUR6_RAT; | P50504, PUR6_SCHOC; | P15567, PUR6_SCHPO; |
| P55195, PUR6_VIGAC; | P21264, PUR6_YEAST; | Q54QE4, PURCE_DICDI; |
|
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