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ENZYME entry: EC 4.1.1.48

Accepted Name
Indole-3-glycerol-phosphate synthase.
Alternative Name(s)
Indoleglycerol phosphate synthetase.
Reaction catalysed
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate <=> 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O
Comment(s)
In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).
Cross-references
PROSITEPDOC00536
BRENDA4.1.1.48
EC2PDB4.1.1.48
ExplorEnz4.1.1.48
PRIAM enzyme-specific profiles4.1.1.48
KEGG Ligand Database for Enzyme Nomenclature4.1.1.48
IUBMB Enzyme Nomenclature4.1.1.48
IntEnz4.1.1.48
MEDLINEFind literature relating to 4.1.1.48
MetaCyc4.1.1.48
UniProtKB/Swiss-Prot
Q8XVE6, TRPC1_RALSO;  O68814, TRPC1_STRCO;  Q8XS01, TRPC2_RALSO;  
Q9Z4X0, TRPC2_STRCO;  O28668, TRPCD_ARCFU;  B0CEU2, TRPC_ACAM1;  
A1TJQ2, TRPC_ACIAC;  P00911, TRPC_ACIAD;  B7I441, TRPC_ACIB5;  
B2HVE7, TRPC_ACIBC;  B0VUS0, TRPC_ACIBS;  A3M785, TRPC_ACIBT;  
B0VBS1, TRPC_ACIBY;  B9MBS5, TRPC_ACIET;  B7JBC0, TRPC_ACIF2;  
B5ERI2, TRPC_ACIF5;  A1W2Z8, TRPC_ACISJ;  Q9Y8T7, TRPC_AERPE;  
Q7CYR2, TRPC_AGRFC;  B9JFD8, TRPC_AGRRK;  B9JX64, TRPC_AGRVS;  
A6TM74, TRPC_ALKMQ;  O67657, TRPC_AQUAE;  P49572, TRPC_ARATH;  
A8ET36, TRPC_ARCB4;  Q5P2G1, TRPC_AROAE;  A0JVL1, TRPC_ARTS2;  
P26938, TRPC_AZOBR;  A8I836, TRPC_AZOC5;  A1KAT2, TRPC_AZOSB;  
C1DHY7, TRPC_AZOVD;  C3P3T8, TRPC_BACAA;  C3LAW0, TRPC_BACAC;  
A0RB62, TRPC_BACAH;  Q81TM0, TRPC_BACAN;  B7JES8, TRPC_BACC0;  
Q73BQ9, TRPC_BACC1;  B7IM74, TRPC_BACC2;  C1ELE8, TRPC_BACC3;  
B7HGZ9, TRPC_BACC4;  B7I0F0, TRPC_BACC7;  B9IU36, TRPC_BACCQ;  
Q81GG7, TRPC_BACCR;  Q63EC9, TRPC_BACCZ;  Q9KCB2, TRPC_BACHD;  
Q6HLU6, TRPC_BACHK;  Q65I33, TRPC_BACLD;  P70937, TRPC_BACMQ;  
A8FEK0, TRPC_BACP2;  P18268, TRPC_BACPU;  Q5WGS3, TRPC_BACSK;  
P03964, TRPC_BACSU;  Q8AAD6, TRPC_BACTN;  A7Z618, TRPC_BACVZ;  
A9VJW0, TRPC_BACWK;  B2IKL7, TRPC_BEII9;  C5BV85, TRPC_BEUC1;  
Q2KU99, TRPC_BORA1;  Q7WEK6, TRPC_BORBR;  Q7W387, TRPC_BORPA;  
A9HY11, TRPC_BORPD;  Q7VU67, TRPC_BORPE;  P94327, TRPC_BRADU;  
A5EK25, TRPC_BRASB;  A4YVD6, TRPC_BRASO;  B2S5Z1, TRPC_BRUA1;  
Q2YRR4, TRPC_BRUA2;  Q57CZ8, TRPC_BRUAB;  A9M5F4, TRPC_BRUC2;  
C0RJB1, TRPC_BRUMB;  P66988, TRPC_BRUME;  A5VQR5, TRPC_BRUO2;  
B0CGT9, TRPC_BRUSI;  P66989, TRPC_BRUSU;  P57366, TRPC_BUCAI;  
P42393, TRPC_BUCAP;  P59459, TRPC_BUCBP;  O68427, TRPC_BUCDN;  
Q44603, TRPC_BUCSC;  B1YSF5, TRPC_BURA4;  Q1BSD2, TRPC_BURCA;  
B1JUU5, TRPC_BURCC;  A0K458, TRPC_BURCH;  Q0BIM8, TRPC_BURCM;  
Q39JZ7, TRPC_BURL3;  A9AJ43, TRPC_BURM1;  A3MFQ4, TRPC_BURM7;  
A2RYI3, TRPC_BURM9;  Q62DD0, TRPC_BURMA;  A1UWA0, TRPC_BURMS;  
A3NZP6, TRPC_BURP0;  Q3JNB0, TRPC_BURP1;  A3NDZ3, TRPC_BURP6;  
Q63QH0, TRPC_BURPS;  Q2SUI0, TRPC_BURTA;  A4JB67, TRPC_BURVG;  
Q8R9M7, TRPC_CALS4;  A8Z6K1, TRPC_CAMC1;  A7GYQ7, TRPC_CAMC5;  
A0RNN3, TRPC_CAMFF;  A7I2Y2, TRPC_CAMHC;  A8FKS2, TRPC_CAMJ8;  
A7H4P0, TRPC_CAMJD;  Q9PI11, TRPC_CAMJE;  A1VYK3, TRPC_CAMJJ;  
Q5HVR3, TRPC_CAMJR;  Q3ABS1, TRPC_CARHZ;  B8GWP9, TRPC_CAUCN;  
Q9A727, TRPC_CAUCR;  B0SYZ4, TRPC_CAUSK;  Q11HU1, TRPC_CHESB;  
Q3AU73, TRPC_CHLCH;  B3EG28, TRPC_CHLL2;  Q3B2C7, TRPC_CHLL7;  
B3QLY7, TRPC_CHLP8;  A1BDW1, TRPC_CHLPD;  A4SG41, TRPC_CHLPM;  
B3QZD6, TRPC_CHLT3;  Q8KBW1, TRPC_CHLTE;  Q7NUI6, TRPC_CHRVO;  
Q97EF3, TRPC_CLOAB;  B8I0V0, TRPC_CLOCE;  B9E149, TRPC_CLOK1;  
A5N7N8, TRPC_CLOK5;  A3DDS7, TRPC_CLOTH;  P06560, TRPC_CORGL;  
Q0K6I0, TRPC_CUPNH;  Q46WU7, TRPC_CUPNJ;  B3R703, TRPC_CUPTR;  
B1WQE4, TRPC_CYAA5;  B8HP79, TRPC_CYAP4;  B7K0H0, TRPC_CYAP8;  
Q47AC7, TRPC_DECAR;  Q3Z6G5, TRPC_DEHM1;  A5FPM3, TRPC_DEHMB;  
Q3ZZ14, TRPC_DEHMC;  Q9RUG0, TRPC_DEIRA;  A9BS06, TRPC_DELAS;  
A8ZZX0, TRPC_DESOH;  Q6AMS4, TRPC_DESPS;  A4J147, TRPC_DESRM;  
A5EVG3, TRPC_DICNV;  Q8X7B7, TRPC_ECO57;  P00909, TRPC_ECOLI;  
C4Z138, TRPC_EUBE2;  B1YLS2, TRPC_EXIS2;  C4KZ66, TRPC_EXISA;  
Q0RFX9, TRPC_FRAAA;  A8LGR8, TRPC_FRASN;  Q5KXU9, TRPC_GEOKA;  
C5D3D6, TRPC_GEOSW;  A4IQ84, TRPC_GEOTN;  Q7NHI0, TRPC_GLOVI;  
P46451, TRPC_HAEIN;  Q5V138, TRPC_HALMA;  Q9HSC1, TRPC_HALSA;  
P18304, TRPC_HALVD;  Q9ZJU8, TRPC_HELPJ;  O25867, TRPC_HELPY;  
A4G1P4, TRPC_HERAR;  Q0C1A2, TRPC_HYPNA;  A6SUH5, TRPC_JANMA;  
A6WC91, TRPC_KINRD;  Q1ISJ1, TRPC_KORVE;  P17217, TRPC_LACCA;  
B3W6W8, TRPC_LACCB;  Q01999, TRPC_LACLA;  A2RK21, TRPC_LACLM;  
Q02YB4, TRPC_LACLS;  Q03CY1, TRPC_LACP3;  A9KL43, TRPC_LACP7;  
Q88WI2, TRPC_LACPL;  C1D7J7, TRPC_LARHH;  Q5X6S0, TRPC_LEGPA;  
A5IG82, TRPC_LEGPC;  Q5ZX99, TRPC_LEGPH;  Q5WY75, TRPC_LEGPL;  
Q6AF68, TRPC_LEIXX;  B1Y7I2, TRPC_LEPCP;  Q72NP6, TRPC_LEPIC;  
Q8F7V2, TRPC_LEPIN;  Q03X00, TRPC_LEUMM;  Q92B79, TRPC_LISIN;  
C1KVS7, TRPC_LISMC;  Q71Z38, TRPC_LISMF;  B8DHB2, TRPC_LISMH;  
Q8Y6Q4, TRPC_LISMO;  A0AJ82, TRPC_LISW6;  A0LA39, TRPC_MAGMM;  
Q58328, TRPC_METJA;  Q8TVJ8, TRPC_METKA;  A4YHD8, TRPC_METS5;  
B8EJS1, TRPC_METSB;  O27694, TRPC_METTH;  P26939, TRPC_METTM;  
B0JTM2, TRPC_MICAN;  C5CBK6, TRPC_MICLC;  A0QHH0, TRPC_MYCA1;  
B1MBV4, TRPC_MYCA9;  P0A633, TRPC_MYCBO;  A1KJ27, TRPC_MYCBP;  
C1ANN3, TRPC_MYCBT;  A4T9N5, TRPC_MYCGI;  B8ZRB9, TRPC_MYCLB;  
Q9X7C7, TRPC_MYCLE;  B2HQX7, TRPC_MYCMM;  Q740P4, TRPC_MYCPA;  
A0QX95, TRPC_MYCS2;  A3Q119, TRPC_MYCSJ;  A1UHJ6, TRPC_MYCSK;  
Q1B7H6, TRPC_MYCSS;  A5U2W7, TRPC_MYCTA;  P9WFX6, TRPC_MYCTO;  
P9WFX7, TRPC_MYCTU;  A0PP28, TRPC_MYCUA;  A1T8X3, TRPC_MYCVP;  
B9LAF4, TRPC_NAUPA;  Q5F645, TRPC_NEIG1;  B4RPF1, TRPC_NEIG2;  
Q9JSN4, TRPC_NEIMA;  Q9K192, TRPC_NEIMB;  A1KRV4, TRPC_NEIMF;  
Q1QMJ9, TRPC_NITHX;  A6Q3P0, TRPC_NITSB;  Q3SRJ3, TRPC_NITWN;  
A1SL44, TRPC_NOCSJ;  Q2G6R0, TRPC_NOVAD;  Q8ESU2, TRPC_OCEIH;  
A6X0L0, TRPC_OCHA4;  B6JG29, TRPC_OLICO;  B1ZW79, TRPC_OPITP;  
A1R5S7, TRPC_PAEAT;  A7HXZ6, TRPC_PARL1;  B2JHI8, TRPC_PARP8;  
B2SZ04, TRPC_PARPJ;  Q13TW4, TRPC_PARXL;  P57855, TRPC_PASMU;  
B4SDV8, TRPC_PELPB;  A9BHQ5, TRPC_PETMO;  B4RBX5, TRPC_PHEZH;  
P24920, TRPC_PHYPR;  Q6L277, TRPC_PICTO;  A4SV52, TRPC_POLAQ;  
A1VTG7, TRPC_POLNA;  B1XSZ1, TRPC_POLNS;  Q123F4, TRPC_POLSJ;  
A3PED0, TRPC_PROM0;  A2C462, TRPC_PROM1;  A8G6A7, TRPC_PROM2;  
A2CB59, TRPC_PROM3;  A9BBR3, TRPC_PROM4;  A2BY04, TRPC_PROM5;  
Q319J2, TRPC_PROM9;  Q7VAT3, TRPC_PROMA;  Q7TV44, TRPC_PROMM;  
Q7TU64, TRPC_PROMP;  A2BSL8, TRPC_PROMS;  Q46JH4, TRPC_PROMT;  
Q48NP7, TRPC_PSE14;  A6UZF2, TRPC_PSEA7;  B7V609, TRPC_PSEA8;  
Q02TB5, TRPC_PSEAB;  P20577, TRPC_PSEAE;  Q1IFZ9, TRPC_PSEE4;  
Q4K503, TRPC_PSEF5;  C3K307, TRPC_PSEFS;  A4XZC5, TRPC_PSEMY;  
A5VXL5, TRPC_PSEP1;  Q3K5V4, TRPC_PSEPF;  B0KK35, TRPC_PSEPG;  
Q88QR6, TRPC_PSEPK;  P20578, TRPC_PSEPU;  B1JE34, TRPC_PSEPW;  
Q88A03, TRPC_PSESM;  A4VHK1, TRPC_PSEU5;  Q9V1G3, TRPC_PYRAB;  
Q8ZYX2, TRPC_PYRAE;  A4WN19, TRPC_PYRAR;  Q8U088, TRPC_PYRFU;  
B1YBK5, TRPC_PYRNV;  B2UDK9, TRPC_RALPJ;  B3Q0L3, TRPC_RHIE6;  
Q2K879, TRPC_RHIEC;  Q1MGE1, TRPC_RHIL3;  Q98ME3, TRPC_RHILO;  
B5ZPY7, TRPC_RHILW;  Q92PR9, TRPC_RHIME;  Q7UKJ7, TRPC_RHOBA;  
Q02584, TRPC_RHOCB;  Q21SE8, TRPC_RHOFT;  Q0SHZ5, TRPC_RHOJR;  
C1AT55, TRPC_RHOOB;  Q2IWB0, TRPC_RHOP2;  Q07NF6, TRPC_RHOP5;  
Q215B9, TRPC_RHOPB;  Q136D2, TRPC_RHOPS;  B3Q6M9, TRPC_RHOPT;  
Q2RT48, TRPC_RHORT;  A3PHK7, TRPC_RHOS1;  Q9ZFA7, TRPC_RHOS4;  
A4WX67, TRPC_RHOS5;  B9KMV0, TRPC_RHOSK;  A7NMZ8, TRPC_ROSCS;  
A5USQ4, TRPC_ROSS1;  A4FLL0, TRPC_SACEN;  Q2S1Z5, TRPC_SALRD;  
Q8Z7D9, TRPC_SALTI;  P00910, TRPC_SALTY;  C3MCF2, TRPC_SINFN;  
A6U9C5, TRPC_SINMW;  A5VBA0, TRPC_SPHWW;  A7X234, TRPC_STAA1;  
A6U1J2, TRPC_STAA2;  Q2FH66, TRPC_STAA3;  Q2FYR6, TRPC_STAA8;  
A5ISQ2, TRPC_STAA9;  Q2YXU9, TRPC_STAAB;  Q9RL78, TRPC_STAAC;  
A6QGS2, TRPC_STAAE;  P66990, TRPC_STAAM;  P66991, TRPC_STAAN;  
Q6GH35, TRPC_STAAR;  Q6G9I9, TRPC_STAAS;  A8Z242, TRPC_STAAT;  
Q8NWU3, TRPC_STAAW;  Q5HPH2, TRPC_STAEQ;  Q8CPB2, TRPC_STAES;  
Q4L677, TRPC_STAHJ;  Q49XH6, TRPC_STAS1;  Q82A84, TRPC_STRAW;  
A8AW03, TRPC_STRGC;  B1W0N8, TRPC_STRGG;  B4SLE8, TRPC_STRM5;  
B2FKL1, TRPC_STRMK;  Q8DVF5, TRPC_STRMU;  Q04IY7, TRPC_STRP2;  
B5E7M5, TRPC_STRP4;  C1C968, TRPC_STRP7;  B1I7S9, TRPC_STRPI;  
B8ZN61, TRPC_STRPJ;  Q97P30, TRPC_STRPN;  B2ISS3, TRPC_STRPS;  
Q8DNM6, TRPC_STRR6;  A3CLL9, TRPC_STRSV;  Q5LYI5, TRPC_STRT1;  
Q5M348, TRPC_STRT2;  Q03JB9, TRPC_STRTD;  C1CG44, TRPC_STRZJ;  
C1CMD5, TRPC_STRZP;  C1CT53, TRPC_STRZT;  Q4J8X3, TRPC_SULAC;  
Q30SM1, TRPC_SULDN;  Q06121, TRPC_SULSO;  Q972A1, TRPC_SULTO;  
Q8KPR4, TRPC_SYNE7;  A0LJ58, TRPC_SYNFM;  Q5N575, TRPC_SYNP6;  
A5GMK4, TRPC_SYNPW;  Q7TTU3, TRPC_SYNPX;  A5GRL0, TRPC_SYNR3;  
Q0IC57, TRPC_SYNS3;  Q3AV87, TRPC_SYNS9;  Q3AL94, TRPC_SYNSC;  
Q55508, TRPC_SYNY3;  Q9HK02, TRPC_THEAC;  Q47QR5, TRPC_THEFY;  
Q9YGB5, TRPC_THEKO;  Q56319, TRPC_THEMA;  B0K8T4, TRPC_THEP3;  
B0K2U1, TRPC_THEPX;  Q979V9, TRPC_THEVO;  Q3SGS2, TRPC_THIDA;  
Q10ZM7, TRPC_TRIEI;  B1GZC0, TRPC_UNCTG;  C5CKE4, TRPC_VARPS;  
A1WH73, TRPC_VEREI;  Q9KST5, TRPC_VIBCH;  P22098, TRPC_VIBPA;  
Q7M831, TRPC_WOLSU;  Q8PQ47, TRPC_XANAC;  Q3BYB5, TRPC_XANC5;  
Q4UZF8, TRPC_XANC8;  Q8PD70, TRPC_XANCP;  Q2NYD7, TRPC_XANOM;  
B2SL03, TRPC_XANOP;  A7INK2, TRPC_XANP2;  B2I6S5, TRPC_XYLF2;  
Q9PGT5, TRPC_XYLFA;  B0U1P0, TRPC_XYLFM;  Q87EX2, TRPC_XYLFT;  
Q8ZEG8, TRPC_YERPE;  Q5NQ36, TRPC_ZYMMO;  Q9XBM3, TRPC_ZYMMT;  
P18483, TRPG_ASPAW;  P05328, TRPG_ASPNG;  Q92411, TRPG_COCHE;  
P0CN87, TRPG_CRYNB;  P27710, TRPG_CRYNH;  P0CN86, TRPG_CRYNJ;  
P06531, TRPG_EMENI;  P00908, TRPG_NEUCR;  P24773, TRPG_PENCH;  
P25170, TRPG_PHACH;  P20409, TRPG_PHYBL;  P09575, TRPG_PICAN;  
Q92370, TRPG_SCHPO;  P00937, TRPG_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
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