Due to maintenance work, this service will not be available Thursday September 18th between 1pm and 4am CEST.

ENZYME entry: EC 4.1.1.90

Accepted Name
Peptidyl-glutamate 4-carboxylase.
Alternative Name(s)
Gamma-glutamyl carboxylase.
Vitamin K-dependent carboxylase.
Reaction catalysed
[Peptidyl]-4-carboxyglutamate + 2,3-epoxyphylloquinone + H(2)O <=> [peptidyl]-glutamate + CO(2) + O(2) + phylloquinone
Comment(s)
  • The enzyme can use various vitamin-K derivatives, including menaquinone, but does not contain iron.
  • In the reverse direction the mechanism appears to involve the generation of a strong base by oxygenation of vitamin K.
  • It catalyzes the post-translational modification of several proteins of the blood-clotting system.
  • 9-12 glutamate residues are converted to 4-carboxyglutamate (Gla) in a specific domain of the target protein.
Cross-references
BRENDA4.1.1.90
EC2PDB4.1.1.90
ExplorEnz4.1.1.90
PRIAM enzyme-specific profiles4.1.1.90
KEGG Ligand Database for Enzyme Nomenclature4.1.1.90
IUBMB Enzyme Nomenclature4.1.1.90
IntEnz4.1.1.90
MEDLINEFind literature relating to 4.1.1.90
MetaCyc4.1.1.90
UniProtKB/Swiss-Prot
Q07175, VKGC_BOVIN;  Q9MYY3, VKGC_DELLE;  P38435, VKGC_HUMAN;  
Q9QYC7, VKGC_MOUSE;  Q5RF50, VKGC_PONAB;  O88496, VKGC_RAT;  
Q9GL59, VKGC_SHEEP;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-