ENZYME entry: EC 4.1.1.94

Accepted Name
Ethylmalonyl-CoA decarboxylase.
Reaction catalysed
(S)-ethylmalonyl-CoA <=> butanoyl-CoA + CO(2)
Comment(s)
  • The enzyme, which exists in all vertebrates, decarboxylates ethylmalonyl-CoA, a potentially toxic compound that is formed in low amounts by the activity of EC 6.4.1.2 and EC 6.4.1.3.
  • It prefers the S isomer, and can decarboxylate (R)-methylmalonyl-CoA with lower efficiency.
  • Cf. EC 4.1.1.41.
  • Formerly EC 4.1.1.n2.
Cross-references
BRENDA4.1.1.94
EC2PDB4.1.1.94
ExplorEnz4.1.1.94
PRIAM enzyme-specific profiles4.1.1.94
KEGG Ligand Database for Enzyme Nomenclature4.1.1.94
IUBMB Enzyme Nomenclature4.1.1.94
IntEnz4.1.1.94
MEDLINEFind literature relating to 4.1.1.94
MetaCyc4.1.1.94
UniProtKB/Swiss-Prot
Q2HJD5, ECHD1_BOVIN;  F1NB38, ECHD1_CHICK;  F1R6N4, ECHD1_DANRE;  
Q9NTX5, ECHD1_HUMAN;  Q9D9V3, ECHD1_MOUSE;  Q5R4W0, ECHD1_PONAB;  
Q6AYG5, ECHD1_RAT;  Q5HZQ8, ECHD1_XENLA;  Q28C91, ECHD1_XENTR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.1.-
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