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ENZYME entry: EC 4.1.2.13

Accepted Name
Fructose-bisphosphate aldolase.
Alternative Name(s)
Aldolase.
D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase.
Fructose-1,6-bisphosphate triosephosphate-lyase.
Reaction catalysed
D-fructose 1,6-bisphosphate <=> glycerone phosphate + D-glyceraldehyde 3-phosphate
Cofactor(s)
Zn(2+).
Comment(s)
  • Also acts on (3S,4R)-ketose 1-phosphates.
  • The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.
  • Formerly EC 4.1.2.7.
Cross-references
PROSITEPDOC00143 ; PDOC00523
BRENDA4.1.2.13
EC2PDB4.1.2.13
ExplorEnz4.1.2.13
PRIAM enzyme-specific profiles4.1.2.13
KEGG Ligand Database for Enzyme Nomenclature4.1.2.13
IUBMB Enzyme Nomenclature4.1.2.13
IntEnz4.1.2.13
MEDLINEFind literature relating to 4.1.2.13
MetaCyc4.1.2.13
UniProtKB/Swiss-Prot
Q4KMC8, ALDCA_DANRE;  Q8JH70, ALDCB_DANRE;  P86980, ALDOA_GADMO;  
P04075, ALDOA_HUMAN;  P05064, ALDOA_MOUSE;  A5A6I5, ALDOA_PANTR;  
Q5NVR5, ALDOA_PONAB;  P00883, ALDOA_RABIT;  P05065, ALDOA_RAT;  
B5DGM7, ALDOA_SALSA;  P86979, ALDOA_THUAL;  Q3T0S5, ALDOB_BOVIN;  
P07341, ALDOB_CHICK;  Q8JH71, ALDOB_DANRE;  P05062, ALDOB_HUMAN;  
Q91Y97, ALDOB_MOUSE;  Q5RFA6, ALDOB_PONAB;  P79226, ALDOB_RABIT;  
P00884, ALDOB_RAT;  P52210, ALDOB_SHEEP;  P53447, ALDOB_SPAAU;  
P53448, ALDOC_CARAU;  P53449, ALDOC_CHICK;  P09972, ALDOC_HUMAN;  
Q9GKW3, ALDOC_MACFA;  P05063, ALDOC_MOUSE;  Q5R1X4, ALDOC_PANTR;  
P09117, ALDOC_RAT;  Q9YG90, ALF1_AERPE;  P54216, ALF1_CAEEL;  
Q9PKH8, ALF1_CHLMU;  Q9Z8Q7, ALF1_CHLPN;  O84217, ALF1_CHLTR;  
Q97TN4, ALF1_CLOAB;  A6LXU8, ALF1_CLOB8;  Q59100, ALF1_CUPNH;  
P0A992, ALF1_ECOL6;  P0A991, ALF1_ECOLI;  Q8RGH3, ALF1_FUSNN;  
B0R3Y0, ALF1_HALS3;  Q9HRI2, ALF1_HALSA;  P53445, ALF1_LETCA;  
Q8ELI2, ALF1_OCEIH;  Q96UH7, ALF1_PARBA;  P46256, ALF1_PEA;  
B2RLG9, ALF1_PORG3;  P60053, ALF1_PORGI;  Q9V2I6, ALF1_PYRAB;  
P58314, ALF1_PYRFU;  O57840, ALF1_PYRHO;  P27995, ALF1_RHOSH;  
A7X6Y6, ALF1_STAA1;  A6U4Y6, ALF1_STAA2;  Q2FDQ4, ALF1_STAA3;  
Q2FV17, ALF1_STAA8;  A5IW31, ALF1_STAA9;  Q2YWF3, ALF1_STAAB;  
Q5HCU6, ALF1_STAAC;  A6QK93, ALF1_STAAE;  P67472, ALF1_STAAM;  
P99117, ALF1_STAAN;  Q6GDJ7, ALF1_STAAR;  Q6G670, ALF1_STAAS;  
A8Z3K5, ALF1_STAAT;  Q8NUM5, ALF1_STAAW;  Q07159, ALF1_STACT;  
Q5HL21, ALF1_STAEQ;  Q8CMY5, ALF1_STAES;  Q4L9B6, ALF1_STAHJ;  
P74309, ALF1_SYNY3;  Q8J308, ALF1_THEKO;  P58315, ALF1_THETK;  
Q73QV3, ALF1_TREDE;  Q8PHB5, ALF1_XANAC;  Q8P5Z7, ALF1_XANCP;  
Q9PF52, ALF1_XYLFA;  Q87AI0, ALF1_XYLFT;  P46563, ALF2_CAEEL;  
Q59101, ALF2_CUPNH;  P53446, ALF2_LETCA;  Q8J0N6, ALF2_PARBA;  
P46257, ALF2_PEA;  P49577, ALF2_PLABA;  P50923, ALF2_RHOCA;  
P29271, ALF2_RHOSH;  Q5HE75, ALF2_STAAC;  P67477, ALF2_STAAM;  
P99075, ALF2_STAAN;  Q6GEV0, ALF2_STAAR;  Q6G7I5, ALF2_STAAS;  
P67478, ALF2_STAAW;  Q5HM97, ALF2_STAEQ;  Q8CNI3, ALF2_STAES;  
Q55664, ALF2_SYNY3;  P17784, ALFC1_ORYSJ;  Q01516, ALFC1_PEA;  
Q10A30, ALFC2_ORYSJ;  Q01517, ALFC2_PEA;  Q5N725, ALFC3_ORYSJ;  
F4KGQ0, ALFC4_ARATH;  O65581, ALFC5_ARATH;  Q9SJQ9, ALFC6_ARATH;  
P22197, ALFC7_ARATH;  Q9LF98, ALFC8_ARATH;  Q42690, ALFC_CHLRE;  
P84722, ALFC_PINST;  P16096, ALFC_SPIOL;  Q9SJU4, ALFP1_ARATH;  
Q944G9, ALFP2_ARATH;  Q9ZU52, ALFP3_ARATH;  Q40677, ALFP_ORYSJ;  
P83155, ALF_ANASL;  Q9HGY9, ALF_ASPOR;  P13243, ALF_BACSU;  
O51401, ALF_BORBU;  P57526, ALF_BUCAI;  Q8K9B2, ALF_BUCAP;  
Q89AB6, ALF_BUCBP;  Q0PAS0, ALF_CAMJE;  A1VYV7, ALF_CAMJJ;  
Q9URB4, ALF_CANAL;  O65735, ALF_CICAR;  P0CJ44, ALF_COCIM;  
P19537, ALF_CORGL;  Q86A67, ALF_DICDI;  P07764, ALF_DROME;  
Q9GP32, ALF_ECHMU;  P0AB72, ALF_ECO57;  P0AB71, ALF_ECOLI;  
O52402, ALF_EDWI9;  Q8SSM8, ALF_ENCCU;  P94453, ALF_GEOSE;  
P44429, ALF_HAEIN;  D4GYE0, ALF_HALVD;  Q9ZMQ6, ALF_HELPJ;  
P56109, ALF_HELPY;  Q9C2U0, ALF_KLULA;  P91759, ALF_LYMST;  
P08440, ALF_MAIZE;  P67476, ALF_MYCBO;  P47269, ALF_MYCGE;  
O69600, ALF_MYCLE;  P75089, ALF_MYCPN;  P9WQA2, ALF_MYCTO;  
P9WQA3, ALF_MYCTU;  P53444, ALF_NEUCR;  Q9XDP3, ALF_NOSCO;  
Q8YNK2, ALF_NOSS1;  Q7KQL9, ALF_PLAF7;  P14223, ALF_PLAFA;  
Q9I5Y1, ALF_PSEAE;  O87796, ALF_PSEST;  P58336, ALF_RHIME;  
P53442, ALF_SCHMA;  P36580, ALF_SCHPO;  P0AB73, ALF_SHIFL;  
P56888, ALF_SINMW;  P29356, ALF_SPIOL;  Q9X8R6, ALF_STRCO;  
Q9ZEM7, ALF_STRGB;  P68905, ALF_STRP1;  P0CZ58, ALF_STRP3;  
Q5XA12, ALF_STRP6;  P68906, ALF_STRP8;  P0A4S1, ALF_STRPN;  
P0CZ59, ALF_STRPQ;  P0A4S2, ALF_STRR6;  Q703I2, ALF_THECA;  
O83668, ALF_TREPA;  P07752, ALF_TRYBB;  Q9PPP3, ALF_UREPA;  
Q56815, ALF_XANFL;  P14540, ALF_YEAST;  Q58980, DKFP_METJA;  
A0RV30, FBPAP_CENSY;  A8A9E4, FBPAP_IGNH4;  Q57747, FBPAP_METJA;  
A4YIZ5, FBPAP_METS5;  D9PUH5, FBPAP_METTM;  Q2RG86, FBPAP_MOOTA;  
B1YAL1, FBPAP_PYRNV;  F9VMT6, FBPAP_SULTO;  Q8NKR9, FBPAP_THEKO;  
Q72K02, FBPAP_THET2;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-