ENZYME entry: EC 4.1.2.43

Accepted Name
3-hexulose-6-phosphate synthase.
Alternative Name(s)
3-hexulose phosphate synthase.
3-hexulosephosphate synthase.
D-arabino-3-hexulose 6-phosphate formaldehyde-lyase.
HPS.
Reaction catalysed
D-arabino-hex-3-ulose 6-phosphate <=> D-ribulose 5-phosphate + formaldehyde
Cofactor(s)
Manganese or magnesium.
Comment(s)
  • Specific for formaldehyde and D-ribulose 5-phosphate as substrates.
  • Ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate.
  • This enzyme, along with EC 5.3.1.27, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds.
  • The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyzes the reactions of this enzyme and EC 5.3.1.27.
Cross-references
BRENDA4.1.2.43
EC2PDB4.1.2.43
ExplorEnz4.1.2.43
PRIAM enzyme-specific profiles4.1.2.43
KEGG Ligand Database for Enzyme Nomenclature4.1.2.43
IUBMB Enzyme Nomenclature4.1.2.43
IntEnz4.1.2.43
MEDLINEFind literature relating to 4.1.2.43
MetaCyc4.1.2.43
UniProtKB/Swiss-Prot
O28964, FAEHP_ARCFU;  Q8THA9, FAEHP_METAC;  A7I6C9, FAEHP_METB6;  
Q46DY5, FAEHP_METBF;  Q12UK3, FAEHP_METBU;  Q2FQ74, FAEHP_METHJ;  
Q58842, FAEHP_METJA;  Q8PXE1, FAEHP_METMA;  A3CUG8, FAEHP_METMJ;  
B8GGX9, FAEHP_METPE;  Q2NE86, FAEHP_METST;  O27518, FAEHP_METTH;  
A0B7U9, FAEHP_METTP;  Q0W644, FAEHP_UNCMA;  Q49WT7, HPS1_STAS1;  
Q49WT0, HPS2_STAS1;  Q49VB7, HPS3_STAS1;  P42405, HPS_BACSU;  
Q48907, HPS_METAM;  Q46DA4, HPS_METBF;  Q9LBW4, HPS_MYCGS;  
Q2FJ70, HPS_STAA3;  Q2G0K7, HPS_STAA8;  Q2YS94, HPS_STAAB;  
Q5HIA5, HPS_STAAC;  Q99W39, HPS_STAAM;  Q7A774, HPS_STAAN;  
Q6GJ99, HPS_STAAR;  Q6GBR7, HPS_STAAS;  Q8NXX1, HPS_STAAW;  
Q5HRH7, HPS_STAEQ;  Q8CQ69, HPS_STAES;  Q4L3P8, HPS_STAHJ;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
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