ENZYME entry: EC 4.1.2.47

Accepted Name
(S)-hydroxynitrile lyase.
Alternative Name(s)
(S)-cyanohydrin producing hydroxynitrile lyase.
(S)-oxynitrilase.
Hydroxynitrile lyase.
Oxynitrilase.
Reaction catalysed
  • An aliphatic (S)-hydroxynitrile <=> cyanide + an aliphatic aldehyde or ketone
  • An aromatic (S)-hydroxynitrile <=> cyanide + an aromatic aldehyde
Comment(s)
  • Hydroxynitrile lyases catalyzes the the cleavage of hydroxynitriles into cyanide and the corresponding aldehyde or ketone.
  • In nature the liberation of cyanide serves as a defense mechanism against herbivores and microbial attack in plants.
  • In vitro the enzymes from Manihot esculenta and Hevea brasiliensis accept a broad range of aliphatic and aromatic carbonyl compounds as substrates and catalyze the formation of (S)-hydroxynitriles.
  • Formerly EC 4.1.2.37 and EC 4.1.2.39.
Cross-references
BRENDA4.1.2.47
EC2PDB4.1.2.47
ExplorEnz4.1.2.47
PRIAM enzyme-specific profiles4.1.2.47
KEGG Ligand Database for Enzyme Nomenclature4.1.2.47
IUBMB Enzyme Nomenclature4.1.2.47
IntEnz4.1.2.47
MEDLINEFind literature relating to 4.1.2.47
MetaCyc4.1.2.47
UniProtKB/Swiss-Prot
P52704, HNL_HEVBR;  P52705, HNL_MANES;  

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