ENZYME entry: EC 4.1.2.48

Accepted Name
Low-specificity L-threonine aldolase.
Reaction catalysed
  • L-threonine <=> glycine + acetaldehyde
  • L-allo-threonine <=> glycine + acetaldehyde
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The low-specificity L-threonine aldolase can act on both L-threonine and L-allo-threonine.
  • The enzyme from Escherichia coli can also act on L-threo-phenylserine and L-erythro-phenylserine.
  • The enzyme can also catalyze the aldol condensation of glycolaldehyde and glycine to form 4-hydroxy-L-threonine, an intermediate of pyridoxal phosphate biosynthesis.
  • Different from EC 4.1.2.5 and EC 4.1.2.49.
Cross-references
BRENDA4.1.2.48
EC2PDB4.1.2.48
ExplorEnz4.1.2.48
PRIAM enzyme-specific profiles4.1.2.48
KEGG Ligand Database for Enzyme Nomenclature4.1.2.48
IUBMB Enzyme Nomenclature4.1.2.48
IntEnz4.1.2.48
MEDLINEFind literature relating to 4.1.2.48
MetaCyc4.1.2.48
UniProtKB/Swiss-Prot
O74267, GLY1_ASHGO;  O13427, GLY1_CANAX;  O13940, GLY1_SCHPO;  
P37303, GLY1_YEAST;  D3DKC4, GLYA_HYDTT;  P58319, LTAE_ECO57;  
P75823, LTAE_ECOLI;  Q9HTF1, LTAE_PSEAE;  O50584, LTAE_PSEUN;  
Q8RXU4, THA1_ARATH;  Q9FPH3, THA2_ARATH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
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