ID 4.1.2.52 DE 4-hydroxy-2-oxoheptanedioate aldolase. AN 2,4-dihydroxyhept-2-enedioate aldolase. AN 4-hydroxy-2-ketoheptanedioate aldolase. AN HHED aldolase. AN HKHD aldolase. CA 4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde. CC -!- The enzyme is also able to catalyze the aldol cleavage of 4-hydroxy- CC 2-oxopentanoate and 4-hydroxy-2-oxohexanoate, and can use CC 2-oxobutanoate as carbonyl donor, with lower efficiency. CC -!- In the reverse direction, is able to condense a range of aldehyde CC acceptors with pyruvate. CC -!- The enzyme from the bacterium Escherichia coli produces a racemic CC mixture of (4R)- and (4S)-hydroxy-2-oxoheptanedioate. CC -!- Formerly EC 4.1.2.n4. DR A8A876, HPCH_ECOHS ; B1IS70, HPCH_ECOLC ; Q47098, HPCH_ECOLX ; DR B6I2N1, HPCH_ECOSE ; B5Y2D2, HPCH_KLEP3 ; A6THU5, HPCH_KLEP7 ; DR B5F1Y9, HPCH_SALA4 ; A9MH59, HPCH_SALAR ; Q57QP9, HPCH_SALCH ; DR B5FR34, HPCH_SALDC ; Q9RPV0, HPCH_SALDU ; B5R043, HPCH_SALEP ; DR B5R6F7, HPCH_SALG2 ; B4TEM9, HPCH_SALHS ; B4T2T9, HPCH_SALNS ; DR Q5PG96, HPCH_SALPA ; A9N6T0, HPCH_SALPB ; C0Q8A0, HPCH_SALPC ; DR B5BBH8, HPCH_SALPK ; B4TSL7, HPCH_SALSV ; Q8Z7P9, HPCH_SALTI ; DR Q8ZQ47, HPCH_SALTY ; B2TZN1, HPCH_SHIB3 ; Q31SY8, HPCH_SHIBS ; DR Q83P19, HPCH_SHIFL ; Q3YU43, HPCH_SHISS ; //