ENZYME entry: EC 4.1.2.8

Accepted Name
Indole-3-glycerol-phosphate lyase.
Alternative Name(s)
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3- phosphate-lyase.
Indole glycerol phosphate hydrolase.
Indole synthase.
Indole-3-glycerol phosphate lyase.
Indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase.
Indoleglycerolphosphate aldolase.
Tryptophan synthase alpha.
TSA.
Reaction catalysed
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <=> indole + D-glyceraldehyde 3-phosphate
Comment(s)
  • Forms part of the defense mechanism against insects and microbial pathogens in the grass family, Gramineae, where it catalyzes one of the steps in the formation of the cyclic hydroxamic acids 2,4- dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7- methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA).
  • Resembles the alpha-subunit of EC 4.2.1.20 but, unlike tryptophan synthase, its activity is independent of the beta-subunit and free indole is released.
Cross-references
PROSITEPDOC00151
BRENDA4.1.2.8
EC2PDB4.1.2.8
ExplorEnz4.1.2.8
PRIAM enzyme-specific profiles4.1.2.8
KEGG Ligand Database for Enzyme Nomenclature4.1.2.8
IUBMB Enzyme Nomenclature4.1.2.8
IntEnz4.1.2.8
MEDLINEFind literature relating to 4.1.2.8
MetaCyc4.1.2.8
UniProtKB/Swiss-Prot
O22765, TRPA1_ARATH;  Q42529, TRPA2_ARATH;  P42390, TRPA_MAIZE;  

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