ENZYME entry: EC 4.1.2.n5

Accepted Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase.
Alternative Name(s)
ADH synthase.
Reaction catalysed
L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate <=> 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + hydroxypyruvaldehyde phosphate
Comment(s)
  • The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
  • The enzyme can also catalyze the cleavage of fructose-1,6- bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate.
Cross-references
UniProtKB/Swiss-Prot
A6UTT2, ADHS_META3;  Q57843, ADHS_METJA;  A4FYB3, ADHS_METM5;  
A9A799, ADHS_METM6;  A6VJZ0, ADHS_METM7;  Q6LZE3, ADHS_METMP;  
A6USC8, ADHS_METVS;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-