ENZYME entry: EC 4.1.3.24

Accepted Name
Malyl-CoA lyase.
Alternative Name(s)
(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase.
L-malyl-CoA lyase.
Malyl-coenzyme A lyase.
Reaction catalysed
  • (S)-malyl-CoA <=> acetyl-CoA + glyoxylate
  • (2R,3S)-2-methylmalyl-CoA <=> propanoyl-CoA + glyoxylate
Comment(s)
  • The enzyme from the bacterium Chloroflexus aurantiacus, which participates in the 3-hydroxypropanoate cycle for carbon assimilation, also has the activity of EC 4.1.3.25.
  • The enzymes from Rhodobacter species are part of acetate assimilation pathways.
  • The reactions are reversible.
Cross-references
BRENDA4.1.3.24
EC2PDB4.1.3.24
ExplorEnz4.1.3.24
PRIAM enzyme-specific profiles4.1.3.24
KEGG Ligand Database for Enzyme Nomenclature4.1.3.24
IUBMB Enzyme Nomenclature4.1.3.24
IntEnz4.1.3.24
MEDLINEFind literature relating to 4.1.3.24
MetaCyc4.1.3.24
UniProtKB/Swiss-Prot
Q5V0X0, AMASY_HALMA;  Q5V463, MCAL_HALMA;  B6E2X2, MCAL_RHOCA;  
D5AR83, MCAL_RHOCB;  A3PGR7, MCAL_RHOS1;  Q3J5L6, MCAL_RHOS4;  
A4WVF5, MCAL_RHOS5;  B9KLE8, MCAL_RHOSK;  A9WC35, MCLA_CHLAA;  
S5N020, MCLA_CHLAU;  

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