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ENZYME entry: EC 4.1.3.39

Accepted Name
4-hydroxy-2-oxovalerate aldolase.
Alternative Name(s)
4-hydroxy-2-ketovalerate aldolase.
4-hydroxy-2-oxopentanoate pyruvate-lyase.
4-hydroxy-2-oxovalerate pyruvate-lyase.
HOA.
Reaction catalysed
(S)-4-hydroxy-2-oxopentanoate <=> acetaldehyde + pyruvate
Cofactor(s)
Mn(2+).
Comment(s)
  • The enzyme from the bacterium Pseudomonas putida is also stimulated by NADH.
  • In some bacterial species, the enzyme forms a bifunctional complex with EC 1.2.1.10.
  • The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.43.
Cross-references
PROSITEPDOC50991
BRENDA4.1.3.39
EC2PDB4.1.3.39
ExplorEnz4.1.3.39
PRIAM enzyme-specific profiles4.1.3.39
KEGG Ligand Database for Enzyme Nomenclature4.1.3.39
IUBMB Enzyme Nomenclature4.1.3.39
IntEnz4.1.3.39
MEDLINEFind literature relating to 4.1.3.39
MetaCyc4.1.3.39
UniProtKB/Swiss-Prot
O86013, BPHF_NOVAR;  O05151, BPHF_RHOJR;  A1K6L9, HOA1_AZOSB;  
C1DMT5, HOA1_AZOVD;  B4EK78, HOA1_BURCJ;  Q397Q9, HOA1_BURL3;  
A4JPX7, HOA1_BURVG;  Q9S152, HOA1_COMTE;  Q1LNS4, HOA1_CUPMC;  
Q0KAQ9, HOA1_CUPNH;  Q47HL8, HOA1_DECAR;  A8LAA1, HOA1_FRASN;  
A2SI33, HOA1_METPP;  B1MH40, HOA1_MYCA9;  B2HGH1, HOA1_MYCMM;  
A0QZU2, HOA1_MYCS2;  A3Q4B9, HOA1_MYCSJ;  A1UM80, HOA1_MYCSK;  
Q1B2X1, HOA1_MYCSS;  A0PR18, HOA1_MYCUA;  A1T2N6, HOA1_MYCVP;  
Q5Z2N2, HOA1_NOCFA;  A1SH77, HOA1_NOCSJ;  A4XF35, HOA1_NOVAD;  
B2JLM6, HOA1_PARP8;  Q143P7, HOA1_PARXL;  P51018, HOA1_PSEP1;  
Q4F8H9, HOA1_PSEPS;  P51017, HOA1_PSEPU;  B1J6Y7, HOA1_PSEPW;  
C0ZPX1, HOA1_RHOE4;  Q0SJD5, HOA1_RHOJR;  C1B7L0, HOA1_RHOOB;  
A8M1N0, HOA1_SALAI;  A5V6T8, HOA1_SPHWW;  A1K6Y4, HOA2_AZOSB;  
C1DRJ0, HOA2_AZOVD;  B4EFI7, HOA2_BURCJ;  Q396P0, HOA2_BURL3;  
A4JW25, HOA2_BURVG;  Q83VZ3, HOA2_COMTE;  Q1LCQ8, HOA2_CUPMC;  
Q0K3S5, HOA2_CUPNH;  Q47GC6, HOA2_DECAR;  A8LEP8, HOA2_FRASN;  
A2SL35, HOA2_METPP;  B1MJT9, HOA2_MYCA9;  B2HI25, HOA2_MYCMM;  
A0R4S6, HOA2_MYCS2;  A3Q6M9, HOA2_MYCSJ;  A1UQA1, HOA2_MYCSK;  
Q1B0P6, HOA2_MYCSS;  A0PUX2, HOA2_MYCUA;  A1TDB7, HOA2_MYCVP;  
Q5YV93, HOA2_NOCFA;  A1SIM3, HOA2_NOCSJ;  A4XDT6, HOA2_NOVAD;  
B2JQW0, HOA2_PARP8;  Q13VU3, HOA2_PARXL;  Q51983, HOA2_PSEP1;  
Q52040, HOA2_PSEPS;  P51019, HOA2_PSEPU;  B1J6Y1, HOA2_PSEPW;  
C0ZU50, HOA2_RHOE4;  Q0S9W9, HOA2_RHOJR;  C1B8I0, HOA2_RHOOB;  
A8M6W8, HOA2_SALAI;  A5V856, HOA2_SPHWW;  A1K893, HOA3_AZOSB;  
C1DN55, HOA3_AZOVD;  Q390P6, HOA3_BURL3;  Q9RHN1, HOA3_COMTE;  
Q0K3N2, HOA3_CUPNH;  Q47B13, HOA3_DECAR;  A1TFQ5, HOA3_MYCVP;  
Q5YUH4, HOA3_NOCFA;  Q13QH6, HOA3_PARXL;  Q0S815, HOA3_RHOJR;  
C1BAJ4, HOA3_RHOOB;  A5VGU4, HOA3_SPHWW;  C1DF10, HOA4_AZOVD;  
Q39LH8, HOA4_BURL3;  Q479H0, HOA4_DECAR;  P51015, HOA4_PARXL;  
Q0S4F8, HOA4_RHOJR;  C1AVG2, HOA4_RHOOB;  Q479E5, HOA5_DECAR;  
Q0S006, HOA5_RHOJR;  C1AYB4, HOA5_RHOOB;  Q0RXC3, HOA6_RHOJR;  
C1BE28, HOA6_RHOOB;  Q0RWN1, HOA7_RHOJR;  A1W2K3, HOA_ACISJ;  
B9JML6, HOA_AGRRK;  Q0A5T5, HOA_ALKEH;  A0RD70, HOA_BACAH;  
Q739I4, HOA_BACC1;  C1ERL7, HOA_BACC3;  Q764S0, HOA_BACPJ;  
Q2KXU5, HOA_BORA1;  C0ZDU6, HOA_BREBN;  A3P825, HOA_BURP0;  
Q3JK55, HOA_BURP1;  A3NML2, HOA_BURP6;  Q63JB1, HOA_BURPS;  
Q2T7S9, HOA_BURTA;  Q3ACM0, HOA_CARHZ;  A9W9U3, HOA_CHLAA;  
B8GBV5, HOA_CHLAD;  B9LCM1, HOA_CHLSY;  Q46NW8, HOA_CUPNJ;  
B2AIJ5, HOA_CUPTR;  B8G187, HOA_DESHD;  A7ZI99, HOA_ECO24;  
B7L508, HOA_ECO55;  Q8X5J8, HOA_ECO57;  B5Z2Q7, HOA_ECO5E;  
B7NK03, HOA_ECO7I;  B7MPB9, HOA_ECO81;  B7M300, HOA_ECO8A;  
A7ZWZ9, HOA_ECOHS;  B1J0S7, HOA_ECOLC;  P51020, HOA_ECOLI;  
B7N8Q9, HOA_ECOLU;  B6HZX8, HOA_ECOSE;  B1LIN7, HOA_ECOSM;  
B0VXM7, HOA_GEOSE;  A4IT42, HOA_GEOTN;  B5XQJ4, HOA_KLEP3;  
A6TAC4, HOA_KLEP7;  B1Y2E5, HOA_LEPCP;  A6W1X1, HOA_MARMS;  
B8ESV2, HOA_METSB;  Q2RHL3, HOA_MOOTA;  A0QAG9, HOA_MYCA1;  
Q7TW97, HOA_MYCBO;  A1KPL9, HOA_MYCBP;  C1AHZ2, HOA_MYCBT;  
A4T7U4, HOA_MYCGI;  Q743Q8, HOA_MYCPA;  A5U8K8, HOA_MYCTA;  
P9WMK4, HOA_MYCTO;  P9WMK5, HOA_MYCTU;  O85977, HOA_NOVAR;  
B2T2S2, HOA_PARPJ;  Q6D796, HOA_PECAS;  A5D523, HOA_PELTS;  
A1VUV1, HOA_POLNA;  Q120N9, HOA_POLSJ;  Q3IEQ9, HOA_PSEHT;  
P51014, HOA_PSES1;  Q9KWS0, HOA_PSESP;  Q9ZI56, HOA_PSEST;  
P51016, HOA_PSEUF;  B2UJF1, HOA_RALPJ;  Q8XRF9, HOA_RALSO;  
Q221U7, HOA_RHOFT;  A7NLU2, HOA_ROSCS;  A5UWE6, HOA_ROSS1;  
A4XAK7, HOA_SALTO;  A8GG86, HOA_SERP5;  B0TTS9, HOA_SHEHH;  
A8H4E9, HOA_SHEPA;  B1KJK9, HOA_SHEWM;  Q3Z554, HOA_SHISS;  
A2TC45, HOA_SPHYA;  Q0PHX9, HOA_SPIAU;  Q99PZ1, HOA_STRCO;  
B1VRH5, HOA_STRGG;  Q9X9Q0, HOA_STRTE;  B9L2J0, HOA_THERP;  
Q53WI0, HOA_THET8;  A1WLL2, HOA_VEREI;  A7IDU6, HOA_XANP2;  

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