ID   4.1.3.44
DE   tRNA 4-demethylwyosine synthase (AdoMet-dependent).
CA   N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-
CA   methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine +
CA   CO2 + H2O + L-methionine.
CC   -!- This enzyme, which is a member of the superfamily of S-adenosyl-L-
CC       methionine-dependent radical (radical AdoMet) enzymes, binds two
CC       [4Fe-4S] clusters.
CC   -!- Carbons C2 and C3 from pyruvate are incorporated into
CC       4-demethylwyosine.
CC   -!- The enzyme is found in eukaryotes where it is part of the pathway for
CC       wybutosine synthesis, and in archaea, where it is involved in the
CC       biosynthesis of archaeal wye bases, such as wyosine, isowyosine,
CC       and methylwyosine.
DR   Q6NUM6, TYW1B_HUMAN;  Q8RXN5, TYW1_ARATH ;  Q08C92, TYW1_DANRE ;
DR   Q9NV66, TYW1_HUMAN ;  Q57705, TYW1_METJA ;  Q8BJM7, TYW1_MOUSE ;
DR   Q8H8N3, TYW1_ORYSJ ;  Q5REF9, TYW1_PONAB ;  Q9V1F9, TYW1_PYRAB ;
DR   O59412, TYW1_PYRHO ;  O59761, TYW1_SCHPO ;  Q2KHP8, TYW1_XENLA ;
DR   Q08960, TYW1_YEAST ;
//