ENZYME entry: EC 4.1.99.1

Accepted Name
Tryptophanase.
Alternative Name(s)
L-tryptophan indole-lyase.
TNase.
Reaction catalysed
L-tryptophan + H(2)O <=> indole + pyruvate + NH(3)
Cofactor(s)
K(+); Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme cleaves a carbon-carbon bond, releasing indole and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • Also catalyzes 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogs of L-cysteine, L-serine and other 3-substituted amino acids.
Cross-references
PROSITEPDOC00667
BRENDA4.1.99.1
EC2PDB4.1.99.1
ExplorEnz4.1.99.1
PRIAM enzyme-specific profiles4.1.99.1
KEGG Ligand Database for Enzyme Nomenclature4.1.99.1
IUBMB Enzyme Nomenclature4.1.99.1
IntEnz4.1.99.1
MEDLINEFind literature relating to 4.1.99.1
MetaCyc4.1.99.1
UniProtKB/Swiss-Prot
P31014, TNAA1_SYMTH;  P31015, TNAA2_SYMTH;  A0KJP3, TNAA_AERHH;  
Q9YCI2, TNAA_AERPE;  A4SNA7, TNAA_AERS4;  Q8R9K5, TNAA_CALS4;  
Q7NYV9, TNAA_CHRVO;  A8AKE2, TNAA_CITK8;  Q894M8, TNAA_CLOTE;  
Q729Z3, TNAA_DESVH;  A1VC86, TNAA_DESVV;  A7ZTR3, TNAA_ECO24;  
B7UMH5, TNAA_ECO27;  B7MGC9, TNAA_ECO45;  B7L853, TNAA_ECO55;  
Q8XB34, TNAA_ECO57;  B5YXB2, TNAA_ECO5E;  B7NR10, TNAA_ECO7I;  
B7N212, TNAA_ECO81;  B7M560, TNAA_ECO8A;  C4ZYY6, TNAA_ECOBW;  
B1X9T7, TNAA_ECODH;  A8A6H0, TNAA_ECOHS;  Q0TB00, TNAA_ECOL5;  
Q8FBV2, TNAA_ECOL6;  B1IX30, TNAA_ECOLC;  P0A853, TNAA_ECOLI;  
B7NF25, TNAA_ECOLU;  B6I3U1, TNAA_ECOSE;  B1LL35, TNAA_ECOSM;  
Q59342, TNAA_ENTAE;  B7LK50, TNAA_ESCF3;  Q4QML4, TNAA_HAEI8;  
O07674, TNAA_HAEIF;  B0R7Q6, TNAA_HALS3;  Q9HMV2, TNAA_HALSA;  
Q0I3R5, TNAA_HISS1;  B0UTZ3, TNAA_HISS2;  Q0C406, TNAA_HYPNA;  
Q9CL27, TNAA_PASMU;  Q7N8C9, TNAA_PHOLL;  Q9ZNA8, TNAA_PROIN;  
P28796, TNAA_PROVU;  O30971, TNAA_RHOCA;  Q2S1V4, TNAA_SALRD;  
A8G097, TNAA_SHESH;  B2TUR7, TNAA_SHIB3;  Q0SYP7, TNAA_SHIF8;  
P0A854, TNAA_SHIFL;  A5EYI0, TNAA_VIBC3;  Q9KN05, TNAA_VIBCH;  
C3LUI5, TNAA_VIBCM;  Q87JQ6, TNAA_VIBPA;  Q8D5Q4, TNAA_VIBVU;  
Q7MCR1, TNAA_VIBVY;  A1JJH3, TNAA_YERE8;  

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