ID 4.1.99.14 DE spore photoproduct lyase. AN SP lyase. CA (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA = a thymidine dimer in CA DNA. CC -!- This enzyme is a member of the 'AdoMet radical' (radical SAM) family. CC -!- The enzyme binds a [4Fe-4S] cluster. CC -!- The cluster is coordinated by 3 cysteines and an exchangeable SAM CC molecule. CC -!- The 5'-deoxy-adenosine radical formed after electron transfer from CC the [4Fe-4S] cluster to the S-adenosyl-L-methionine, initiates the CC repair by abstracting the C-6 hydrogen of the spore photoproduct CC lesion. CC -!- During the second part of the repair process the SAM molecule is CC regenerated. DR Q97L63, SPLB_CLOAB ; P37956, SPL_BACSU ; C9RZ55, SPL_GEOSY ; //