ID 4.1.99.17 DE phosphomethylpyrimidine synthase. CA 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = CA 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CA CO + formate + 3 H(+) + L-methionine. CC -!- Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an CC exchangeable S-adenosyl-L-methionine molecule. CC -!- The first stage of catalysis is reduction of the S-adenosyl-L- CC methionine to produce L-methionine and a 5'-deoxyadenosin-5'-yl CC radical that is crucial for the conversion of the substrate. CC -!- Part of the pathway for thiamine biosynthesis. DR Q8TPW4, THIC1_METAC; Q46EW5, THIC1_METBF; Q8Q0F4, THIC1_METMA; DR Q2NHI8, THIC1_METST; O27586, THIC1_METTH; Q97YJ8, THIC1_SACS2; DR Q3A7P7, THIC1_SYNC1; Q8TI28, THIC2_METAC; Q46AN2, THIC2_METBF; DR Q8PY39, THIC2_METMA; Q2NHG6, THIC2_METST; O27617, THIC2_METTH; DR Q97X14, THIC2_SACS2; Q3A2D2, THIC2_SYNC1; B0CCG9, THIC_ACAM1 ; DR Q6FFB6, THIC_ACIAD ; B7H1M6, THIC_ACIB3 ; B7I331, THIC_ACIB5 ; DR B2I1W2, THIC_ACIBC ; B0VMD7, THIC_ACIBS ; A3M1D2, THIC_ACIBT ; DR B0VDF1, THIC_ACIBY ; B9MFQ3, THIC_ACIET ; B7J7C4, THIC_ACIF2 ; DR B5EQ61, THIC_ACIF5 ; A1WBZ7, THIC_ACISJ ; B6JI86, THIC_AFIC5 ; DR Q8UCC9, THIC_AGRFC ; Q21XR6, THIC_ALBFT ; Q5E8W9, THIC_ALIF1 ; DR B5FF66, THIC_ALIFM ; B6EGV1, THIC_ALISL ; A6TVU5, THIC_ALKMQ ; DR A8MEI9, THIC_ALKOO ; B9K253, THIC_ALLAM ; B4S2W4, THIC_ALTMD ; DR B8JAC3, THIC_ANAD2 ; Q2IID8, THIC_ANADE ; A7HCC3, THIC_ANADF ; DR Q5PB42, THIC_ANAMM ; Q2GKB1, THIC_ANAPZ ; B4UDM7, THIC_ANASK ; DR O67259, THIC_AQUAE ; O82392, THIC_ARATH ; O30259, THIC_ARCFU ; DR Q5P6L3, THIC_AROAE ; A1K3Q2, THIC_AZOSB ; C3P178, THIC_BACAA ; DR C3LEJ7, THIC_BACAC ; A0RL17, THIC_BACAH ; Q81WY7, THIC_BACAN ; DR B7JGF0, THIC_BACC0 ; P61423, THIC_BACC1 ; B7IPY9, THIC_BACC2 ; DR C1EZL5, THIC_BACC3 ; B7HEM8, THIC_BACC4 ; B7HX62, THIC_BACC7 ; DR A7GUZ5, THIC_BACCN ; B9J5N4, THIC_BACCQ ; Q815D5, THIC_BACCR ; DR Q631C7, THIC_BACCZ ; Q5LCA5, THIC_BACFN ; Q64T99, THIC_BACFR ; DR Q6HB59, THIC_BACHK ; Q65M65, THIC_BACLD ; A9VR68, THIC_BACMK ; DR A8FFR8, THIC_BACP2 ; P45740, THIC_BACSU ; Q8AA15, THIC_BACTN ; DR A7Z2P5, THIC_BACVZ ; A1US11, THIC_BARBK ; Q6G477, THIC_BARHE ; DR Q6G099, THIC_BARQU ; A9IRH7, THIC_BART1 ; Q1LU45, THIC_BAUCH ; DR Q2L083, THIC_BORA1 ; Q7WQM6, THIC_BORBR ; Q7W1Q0, THIC_BORPA ; DR A9IFG8, THIC_BORPD ; Q7W0D7, THIC_BORPE ; Q89FP0, THIC_BRADU ; DR A5EPQ5, THIC_BRASB ; A4YZQ6, THIC_BRASO ; B1YW60, THIC_BURA4 ; DR A0K648, THIC_BURCH ; B4ED40, THIC_BURCJ ; Q0BGQ9, THIC_BURCM ; DR Q39HY9, THIC_BURL3 ; A9ACX9, THIC_BURM1 ; A3MIG6, THIC_BURM7 ; DR A2S3Z6, THIC_BURM9 ; Q62FE9, THIC_BURMA ; A1V2S9, THIC_BURMS ; DR B1JYX0, THIC_BURO0 ; Q1BXK3, THIC_BURO1 ; A3NTK3, THIC_BURP0 ; DR Q3JU20, THIC_BURP1 ; A3N7W7, THIC_BURP6 ; Q63VF5, THIC_BURPS ; DR Q2SUP3, THIC_BURTA ; A4JCZ0, THIC_BURVG ; Q8R9P1, THIC_CALS4 ; DR A0RN29, THIC_CAMFF ; A7I162, THIC_CAMHC ; A8FKN8, THIC_CAMJ8 ; DR A7H4T0, THIC_CAMJD ; Q9PI55, THIC_CAMJE ; A1VYG9, THIC_CAMJJ ; DR Q5HW14, THIC_CAMJR ; Q3AE33, THIC_CARHZ ; B0T2Q1, THIC_CAUSK ; DR Q9A6Q5, THIC_CAUVC ; B8GX84, THIC_CAUVN ; B3PCK0, THIC_CELJU ; DR Q3ATM0, THIC_CHLCH ; B3EE09, THIC_CHLL2 ; Q3B2V9, THIC_CHLL3 ; DR B3QPT5, THIC_CHLP8 ; B3EPH6, THIC_CHLPB ; A4SFM6, THIC_CHLPM ; DR Q8KCH9, THIC_CHLTE ; Q7P1H8, THIC_CHRVO ; A8AKS9, THIC_CITK8 ; DR Q97EU2, THIC_CLOAB ; A7FXG9, THIC_CLOB1 ; C3L2Y4, THIC_CLOB6 ; DR A5I5Z5, THIC_CLOBH ; C1FVP6, THIC_CLOBJ ; B1ILH9, THIC_CLOBK ; DR A7GHD2, THIC_CLOBL ; B1KZJ7, THIC_CLOBM ; Q186R0, THIC_CLOD6 ; DR B9E2H5, THIC_CLOK1 ; A5N937, THIC_CLOK5 ; A0Q1U9, THIC_CLONN ; DR Q0TTB7, THIC_CLOP1 ; Q8XMK9, THIC_CLOPE ; Q0SV55, THIC_CLOPS ; DR Q897B2, THIC_CLOTE ; Q48A96, THIC_COLP3 ; P61424, THIC_CORDI ; DR Q8FPT3, THIC_COREF ; A4QDR7, THIC_CORGB ; Q8NQW7, THIC_CORGL ; DR Q4JVZ0, THIC_CORJK ; B6J5W3, THIC_COXB1 ; B6J1X8, THIC_COXB2 ; DR A9KGN7, THIC_COXBN ; Q83EJ0, THIC_COXBU ; B1WW40, THIC_CROS5 ; DR Q1LS28, THIC_CUPMC ; Q0KF34, THIC_CUPNH ; Q476U6, THIC_CUPPJ ; DR B2AGF3, THIC_CUPTR ; B8HNW1, THIC_CYAP4 ; Q478T2, THIC_DECAR ; DR Q3Z8E2, THIC_DEHM1 ; A5FR94, THIC_DEHMB ; Q3ZXE1, THIC_DEHMC ; DR Q1IX15, THIC_DEIGD ; Q9RYX8, THIC_DEIRA ; B1I672, THIC_DESAP ; DR B8FUD2, THIC_DESHD ; A8ZVP4, THIC_DESOH ; Q6AK99, THIC_DESPS ; DR A4J8J1, THIC_DESRM ; A7ZUK9, THIC_ECO24 ; B7UPE9, THIC_ECO27 ; DR B7MIY0, THIC_ECO45 ; B7LA88, THIC_ECO55 ; Q8X6X9, THIC_ECO57 ; DR B5Z090, THIC_ECO5E ; B7NRS7, THIC_ECO7I ; B7MRC0, THIC_ECO81 ; DR B7M7Q3, THIC_ECO8A ; C5A0T5, THIC_ECOBW ; B1XBZ7, THIC_ECODH ; DR A8A794, THIC_ECOHS ; A1AIG5, THIC_ECOK1 ; Q0TA71, THIC_ECOL5 ; DR Q8FB77, THIC_ECOL6 ; B1IUQ3, THIC_ECOLC ; P30136, THIC_ECOLI ; DR B7NFT5, THIC_ECOLU ; B6I5K5, THIC_ECOSE ; B1LNU6, THIC_ECOSM ; DR Q3YSI0, THIC_EHRCJ ; Q2GG37, THIC_EHRCR ; Q5FHG9, THIC_EHRRG ; DR Q5HBN2, THIC_EHRRW ; Q2N8D9, THIC_ERYLH ; B7LUK8, THIC_ESCF3 ; DR B0S3A6, THIC_FINM2 ; Q2JG22, THIC_FRACC ; Q8RI60, THIC_FUSNN ; DR Q5L325, THIC_GEOKA ; Q39RJ6, THIC_GEOMG ; C5D571, THIC_GEOSW ; DR A4IK74, THIC_GEOTN ; B7KDN8, THIC_GLOC7 ; Q7NLK5, THIC_GLOVI ; DR Q5FNT7, THIC_GLUOX ; Q2SQL8, THIC_HAHCH ; Q9KBJ4, THIC_HALH5 ; DR Q5V2X0, THIC_HALMA ; B0R400, THIC_HALS3 ; Q9HRG2, THIC_HALSA ; DR Q7VFU4, THIC_HELHP ; A4G224, THIC_HERAR ; Q31JC9, THIC_HYDCU ; DR Q5QUD0, THIC_IDILO ; A8A8N6, THIC_IGNH4 ; A6SUX7, THIC_JANMA ; DR B5XYE4, THIC_KLEP3 ; A6TGQ1, THIC_KLEP7 ; Q04VF1, THIC_LEPBJ ; DR Q04Y23, THIC_LEPBL ; B1Y5I3, THIC_LEPCP ; Q72NZ8, THIC_LEPIC ; DR Q8F7G5, THIC_LEPIN ; Q2WAV0, THIC_MAGSA ; A6UT74, THIC_META3 ; DR A7I8Q1, THIC_METB6 ; Q603T9, THIC_METCA ; Q2FQY7, THIC_METHJ ; DR Q58432, THIC_METJA ; Q8TZ33, THIC_METKA ; A2SU66, THIC_METLZ ; DR A4G002, THIC_METM5 ; A9A8A9, THIC_METM6 ; A6VIH6, THIC_METM7 ; DR A3CVT7, THIC_METMJ ; P61428, THIC_METMP ; B8GKY4, THIC_METPE ; DR A2SG83, THIC_METPP ; A6URG5, THIC_METVS ; B0JSK4, THIC_MICAN ; DR Q2RIM5, THIC_MOOTA ; A0QLS0, THIC_MYCA1 ; B1MIP8, THIC_MYCA9 ; DR P66912, THIC_MYCBO ; A1KFP5, THIC_MYCBP ; C1AK99, THIC_MYCBT ; DR B8ZU90, THIC_MYCLB ; Q9ZBL0, THIC_MYCLE ; B2HQM5, THIC_MYCMM ; DR P61426, THIC_MYCPA ; A5TZE9, THIC_MYCTA ; P9WG78, THIC_MYCTO ; DR P9WG79, THIC_MYCTU ; A0PTS1, THIC_MYCUA ; Q1D4L3, THIC_MYXXD ; DR Q3IRP7, THIC_NATPD ; B9L811, THIC_NAUPA ; Q5F588, THIC_NEIG1 ; DR A9M0A4, THIC_NEIM0 ; Q9JWF3, THIC_NEIMA ; Q9JXI0, THIC_NEIMB ; DR A1KWC0, THIC_NEIMF ; Q0AJI9, THIC_NITEC ; Q82Y50, THIC_NITEU ; DR Q1QJD3, THIC_NITHX ; Q2Y6P4, THIC_NITMU ; Q3J7C1, THIC_NITOC ; DR A6Q2K1, THIC_NITSB ; Q3SPS0, THIC_NITWN ; Q5YNS3, THIC_NOCFA ; DR B2J323, THIC_NOSP7 ; Q8YY69, THIC_NOSS1 ; Q2G7A9, THIC_NOVAD ; DR A1TKD9, THIC_PARC0 ; A1B684, THIC_PARDP ; A7HV30, THIC_PARL1 ; DR Q7U9W2, THIC_PARMW ; B2JJF7, THIC_PARP8 ; B2SXY6, THIC_PARPJ ; DR Q13WN4, THIC_PARXL ; Q6DAM0, THIC_PECAS ; B4SBF6, THIC_PELPB ; DR A5D4K5, THIC_PELTS ; Q7N963, THIC_PHOLL ; Q6LVY0, THIC_PHOPR ; DR B1XIG4, THIC_PICP2 ; A1VI67, THIC_POLNA ; Q12HI8, THIC_POLSJ ; DR B2RH34, THIC_PORG3 ; Q7MT71, THIC_PORGI ; B4S9A9, THIC_PROA2 ; DR A3PFA2, THIC_PROM0 ; A2C559, THIC_PROM1 ; A8G7B7, THIC_PROM2 ; DR A2C642, THIC_PROM3 ; A9BD54, THIC_PROM4 ; A2BYZ5, THIC_PROM5 ; DR Q318D0, THIC_PROM9 ; Q7V9Q8, THIC_PROMA ; Q7V906, THIC_PROMM ; DR Q7UZP7, THIC_PROMP ; A2BTJ3, THIC_PROMS ; Q46IK0, THIC_PROMT ; DR Q48P32, THIC_PSE14 ; A6VD86, THIC_PSEA7 ; B7V362, THIC_PSEA8 ; DR Q02F45, THIC_PSEAB ; Q9HUJ2, THIC_PSEAE ; Q1I419, THIC_PSEE4 ; DR Q4KJA1, THIC_PSEF5 ; A8F821, THIC_PSELT ; A4XPW1, THIC_PSEMY ; DR A5W9V8, THIC_PSEP1 ; Q3KJ20, THIC_PSEPF ; B0KL24, THIC_PSEPG ; DR Q88DA5, THIC_PSEPK ; B1JAG3, THIC_PSEPW ; Q87VG1, THIC_PSESM ; DR Q3IFN9, THIC_PSET1 ; Q4ZZ08, THIC_PSEU2 ; Q4FVJ8, THIC_PSYA2 ; DR Q1QEM6, THIC_PSYCK ; Q9V0X8, THIC_PYRAB ; Q8ZZC0, THIC_PYRAE ; DR Q8U0Q4, THIC_PYRFU ; Q8Y368, THIC_RALN1 ; Q2K206, THIC_RHIEC ; DR Q98AZ3, THIC_RHILO ; Q92TI9, THIC_RHIME ; B9JMY1, THIC_RHIR8 ; DR A5VB82, THIC_RHIWR ; Q7UP26, THIC_RHOBA ; Q2IYP8, THIC_RHOP2 ; DR Q07PX1, THIC_RHOP5 ; P61427, THIC_RHOPA ; Q216H0, THIC_RHOPB ; DR Q133T3, THIC_RHOPS ; B3QFS9, THIC_RHOPT ; Q2RST7, THIC_RHORT ; DR B7K508, THIC_RIPO1 ; Q1GEY0, THIC_RUEST ; A1AW65, THIC_RUTMC ; DR Q21NU6, THIC_SACD2 ; B5F1H7, THIC_SALA4 ; A9MHD6, THIC_SALAR ; DR Q57H61, THIC_SALCH ; B5FQK9, THIC_SALDC ; B5QYE9, THIC_SALEP ; DR B5RFJ0, THIC_SALG2 ; B4TCT3, THIC_SALHS ; B4T0Z6, THIC_SALNS ; DR Q5PKA6, THIC_SALPA ; A9N0K6, THIC_SALPB ; C0Q2S6, THIC_SALPC ; DR B5BJR3, THIC_SALPK ; B4TQK4, THIC_SALSV ; Q8Z326, THIC_SALTI ; DR Q9L9I7, THIC_SALTY ; A1S6Q9, THIC_SHEAM ; Q12NC2, THIC_SHEDO ; DR B0TRP7, THIC_SHEHH ; A3QER4, THIC_SHELP ; Q8EED7, THIC_SHEON ; DR A8H566, THIC_SHEPA ; A4Y6R2, THIC_SHEPC ; A8FUU9, THIC_SHESH ; DR B1KHI4, THIC_SHEWM ; B2TWI1, THIC_SHIB3 ; Q31U03, THIC_SHIBS ; DR Q32AG7, THIC_SHIDS ; Q0SY06, THIC_SHIF8 ; Q83PB8, THIC_SHIFL ; DR Q3YUZ0, THIC_SHISS ; Q028Z8, THIC_SOLUE ; Q1GQJ3, THIC_SPHAL ; DR Q82FI7, THIC_STRAW ; Q9X9U0, THIC_STRCO ; B1VPA3, THIC_STRGG ; DR B4SI60, THIC_STRM5 ; B2FT70, THIC_STRMK ; A4VR38, THIC_STUS1 ; DR Q4JCB9, THIC_SULAC ; Q30QG8, THIC_SULDN ; C3N4K5, THIC_SULIA ; DR C4KG47, THIC_SULIK ; C3MMC3, THIC_SULIL ; C3MX60, THIC_SULIM ; DR Q96ZH0, THIC_SULTO ; Q2LSU0, THIC_SYNAS ; Q31P93, THIC_SYNE7 ; DR Q2JY68, THIC_SYNJA ; Q2JPK6, THIC_SYNJB ; Q5N4X6, THIC_SYNP6 ; DR A5GI51, THIC_SYNPW ; A5GQ73, THIC_SYNR3 ; Q0IDV6, THIC_SYNS3 ; DR Q3B0I6, THIC_SYNS9 ; Q3AND3, THIC_SYNSC ; Q0AZ84, THIC_SYNWW ; DR Q55894, THIC_SYNY3 ; C5BTK7, THIC_TERTT ; C5A6A9, THIC_THEGJ ; DR Q5JD26, THIC_THEKO ; Q9WZP5, THIC_THEMA ; B9KAI3, THIC_THENN ; DR A5IIZ7, THIC_THEP1 ; B0KD66, THIC_THEP3 ; B0K5Z9, THIC_THEPX ; DR B1LCP2, THIC_THESQ ; Q72KP6, THIC_THET2 ; Q5SKG5, THIC_THET8 ; DR Q8DLZ2, THIC_THEVB ; B5YJ75, THIC_THEYD ; Q3SFG3, THIC_THIDA ; DR Q111Z9, THIC_TRIEI ; Q3MGA3, THIC_TRIV2 ; C5CM74, THIC_VARPS ; DR A5CX15, THIC_VESOH ; B7VMV7, THIC_VIBA3 ; A7N141, THIC_VIBC1 ; DR A5F4D2, THIC_VIBC3 ; Q9KVS8, THIC_VIBCH ; C3LPQ3, THIC_VIBCM ; DR Q87KF0, THIC_VIBPA ; Q8DDL4, THIC_VIBVU ; Q7MGM3, THIC_VIBVY ; DR Q8D247, THIC_WIGBR ; Q7M818, THIC_WOLSU ; Q8PH13, THIC_XANAC ; DR Q3BPK7, THIC_XANC5 ; Q4UYF2, THIC_XANC8 ; B0RP37, THIC_XANCB ; DR Q8P5L9, THIC_XANCP ; Q2P755, THIC_XANOM ; B2SNG3, THIC_XANOP ; DR Q5H4C0, THIC_XANOR ; Q9PC93, THIC_XYLFA ; Q87CY6, THIC_XYLFT ; DR Q8ZAQ2, THIC_YERPE ; Q66FP5, THIC_YERPS ; Q5NR58, THIC_ZYMMO ; DR Q8G7X1, THIEC_BIFLO; //