To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 4.1.99.20

Accepted Name
3-amino-4-hydroxybenzoate synthase.
Alternative Name(s)
3,4-AHBA synthase.
Reaction catalysed
2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> 3-amino-4-hydroxybenzoate + phosphate + 2 H(2)O
Cofactor(s)
Mn(2+).
Comment(s)
  • The reaction is suggested to take place in several steps.
  • Schiff base formation, double bond migration and dephosphorylation followed by ring opening and closing to form a pyrrolidine ring, and finally dehydration to form the product 3-amino-4- hydroxybenzoate.
  • In the bacterium Streptomyces griseus the enzyme is involved in biosynthesis of grixazone, a yellow pigment that contains a phenoxazinone chromophore.
  • Formerly EC 4.3.3.n1.
Cross-references
BRENDA4.1.99.20
EC2PDB4.1.99.20
ExplorEnz4.1.99.20
PRIAM enzyme-specific profiles4.1.99.20
KEGG Ligand Database for Enzyme Nomenclature4.1.99.20
IUBMB Enzyme Nomenclature4.1.99.20
IntEnz4.1.99.20
MEDLINEFind literature relating to 4.1.99.20
MetaCyc4.1.99.20
UniProtKB/Swiss-Prot
B1VTI7, GRIH_STRGG;  A0JC76, GRIH_STRGR;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-