ENZYME entry: EC 4.1.99.20

Accepted Name
3-amino-4-hydroxybenzoate synthase.
Alternative Name(s)
3,4-AHBA synthase.
Reaction catalysed
2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate <=> 3-amino-4-hydroxybenzoate + phosphate + 2 H(2)O
Cofactor(s)
Mn(2+).
Comment(s)
  • The reaction is suggested to take place in several steps.
  • Schiff base formation, double bond migration and dephosphorylation followed by ring opening and closing to form a pyrrolidine ring, and finally dehydration to form the product 3-amino-4- hydroxybenzoate.
  • In the bacterium Streptomyces griseus the enzyme is involved in biosynthesis of grixazone, a yellow pigment that contains a phenoxazinone chromophore.
  • Formerly EC 4.3.3.n1.
Cross-references
BRENDA4.1.99.20
EC2PDB4.1.99.20
ExplorEnz4.1.99.20
PRIAM enzyme-specific profiles4.1.99.20
KEGG Ligand Database for Enzyme Nomenclature4.1.99.20
IUBMB Enzyme Nomenclature4.1.99.20
IntEnz4.1.99.20
MEDLINEFind literature relating to 4.1.99.20
MetaCyc4.1.99.20
UniProtKB/Swiss-Prot
B1VTI7, GRIH_STRGG;  A0JC76, GRIH_STRGR;  

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