ID   4.2.1.115
DE   UDP-N-acetylglucosamine 4,6-dehydratase (inverting).
AN   UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase.
CA   UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-
CA   beta-L-arabino-hex-4-ulose.
CC   -!- The first enzyme in the biosynthetic pathway of pseudaminic acid,
CC       a sialic-acid-like sugar that is unique to bacteria and is used by
CC       Helicobacter pylori to modify its flagellin.
CC   -!- Plays a critical role in H.pylori's pathogenesis, being involved in
CC       the synthesis of both functional flagella and lipopolysaccharides.
CC   -!- Completely inhibited by UDP-alpha-D-galactose.
CC   -!- The reaction results in the chirality of the C-5 atom being inverted.
CC   -!- It is thought that Lys-133 acts sequentially as a catalytic acid,
CC       protonating the C-6 hydroxy group and as a catalytic base,
CC       abstracting the C-5 proton, resulting in the elimination of water.
DR   Q0P8W4, PSEB_CAMJE ;  Q5QKR8, PSEB_CAMJJ ;  O25511, PSEB_HELPY ;
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