ENZYME entry: EC 4.2.1.117

Accepted Name
2-methylcitrate dehydratase (2-methyl-trans-aconitate forming).
Reaction catalysed
(2S,3S)-2-methylcitrate <=> 2-methyl-trans-aconitate + H(2)O
Cofactor(s)
Iron-sulfur.
Comment(s)
  • Catalyzes the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer).
  • Part of a propanoate degradation pathway.
  • The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher.
  • 2-methylisocitrate and isocitrate were not substrates.
Cross-references
BRENDA4.2.1.117
EC2PDB4.2.1.117
ExplorEnz4.2.1.117
PRIAM enzyme-specific profiles4.2.1.117
KEGG Ligand Database for Enzyme Nomenclature4.2.1.117
IUBMB Enzyme Nomenclature4.2.1.117
IntEnz4.2.1.117
MEDLINEFind literature relating to 4.2.1.117
MetaCyc4.2.1.117
UniProtKB/Swiss-Prot
Q8EJW3, ACND_SHEON

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
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