ENZYME entry: EC 4.2.1.119

Accepted Name
Enoyl-CoA hydratase 2.
Alternative Name(s)
2-enoyl-CoA hydratase 2.
D-3-hydroxyacyl-CoA hydro-lyase.
D-specific 2-trans-enoyl-CoA hydratase.
ECH2.
Reaction catalysed
(3R)-3-hydroxyacyl-CoA <=> (2E)-2-enoyl-CoA + H(2)O
Comment(s)
  • This enzyme catalyzes a hydration step in peroxisomal beta-oxidation.
  • The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units.
  • The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes.
  • 2-Enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2.
Cross-references
BRENDA4.2.1.119
EC2PDB4.2.1.119
ExplorEnz4.2.1.119
PRIAM enzyme-specific profiles4.2.1.119
KEGG Ligand Database for Enzyme Nomenclature4.2.1.119
IUBMB Enzyme Nomenclature4.2.1.119
IntEnz4.2.1.119
MEDLINEFind literature relating to 4.2.1.119
MetaCyc4.2.1.119
UniProtKB/Swiss-Prot
Q9VXJ0, DHB4_DROME;  P51659, DHB4_HUMAN;  P51660, DHB4_MOUSE;  
P97852, DHB4_RAT;  Q8VYI3, ECH2_ARATH;  P22414, FOX2_CANTR;  
Q01373, FOX2_NEUCR;  Q02207, FOX2_YEAST;  Q54XZ0, MFEB_DICDI;  
O32472, PHAJ_AERCA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
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