ENZYME entry: EC 4.2.1.119
| Accepted Name |
|---|
| Enoyl-CoA hydratase 2.
|
| Alternative Name(s) |
|---|
| 2-enoyl-CoA hydratase 2. |
| D-3-hydroxyacyl-CoA hydro-lyase. |
| D-specific 2-trans-enoyl-CoA hydratase. |
| ECH2. |
| Reaction catalysed |
|---|
| (3R)-3-hydroxyacyl-CoA <=> (2E)-2-enoyl-CoA + H(2)O |
| Comment(s) |
|---|
- This enzyme catalyzes a hydration step in peroxisomal beta-oxidation.
- The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme
composed of three functional units: (3R)-hydroxyacyl-CoA
dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein
2-like units.
- The enzymes from Aeromonas caviae and Arabidopsis thaliana are
monofunctional enzymes.
- 2-Enoyl-CoA hydratase 3 from Candida tropicalis is a part from
multifunctional enzyme type 2.
|
| Cross-references |
|---|
| BRENDA | 4.2.1.119 |
| EC2PDB | 4.2.1.119 |
| ExplorEnz | 4.2.1.119 |
| PRIAM enzyme-specific profiles | 4.2.1.119 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.1.119 |
| IUBMB Enzyme Nomenclature | 4.2.1.119 |
| IntEnz | 4.2.1.119 |
| MEDLINE | Find literature relating to 4.2.1.119 |
| MetaCyc | 4.2.1.119 |
| UniProtKB/Swiss-Prot |
| Q9VXJ0, DHB4_DROME; | P51659, DHB4_HUMAN; | P51660, DHB4_MOUSE; |
| P97852, DHB4_RAT; | Q8VYI3, ECH2_ARATH; | P22414, FOX2_CANTR; |
| Q01373, FOX2_NEUCR; | Q02207, FOX2_YEAST; | Q54XZ0, MFEB_DICDI; |
| O32472, PHAJ_AERPU; |
|
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