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ENZYME entry: EC 4.2.1.130

Accepted Name
D-lactate dehydratase.
Alternative Name(s)
Glyoxylase III.
Reaction catalysed
(R)-lactate <=> methylglyoxal + H(2)O
Comment(s)
  • The enzyme converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step.
  • The other known route for this conversion is the two-step GSH- dependent pathway catalyzed by EC 4.4.1.5 and EC 3.1.2.6.
Cross-references
BRENDA4.2.1.130
EC2PDB4.2.1.130
ExplorEnz4.2.1.130
PRIAM enzyme-specific profiles4.2.1.130
KEGG Ligand Database for Enzyme Nomenclature4.2.1.130
IUBMB Enzyme Nomenclature4.2.1.130
IntEnz4.2.1.130
MEDLINEFind literature relating to 4.2.1.130
MetaCyc4.2.1.130
UniProtKB/Swiss-Prot
P90994, DJ11_CAEEL;  O16228, DJ12_CAEEL;  Q10356, DJ1_SCHPO;  
P31658, HCHA_ECOLI;  Q5AF03, HSP31_CANAL;  O74914, HSP31_SCHPO;  
Q04432, HSP31_YEAST;  Q09675, HSP32_SCHPO;  Q08992, HSP32_YEAST;  
O43084, HSP33_SCHPO;  Q08914, HSP33_YEAST;  Q10092, HSP34_SCHPO;  
Q09918, HSP35_SCHPO;  Q04902, SNO4_YEAST;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-