ENZYME entry: EC 4.2.1.130

Accepted Name
D-lactate dehydratase.
Alternative Name(s)
Glyoxylase III.
Reaction catalysed
(R)-lactate <=> methylglyoxal + H(2)O
Comment(s)
  • The enzyme converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step.
  • The other known route for this conversion is the two-step GSH- dependent pathway catalyzed by EC 4.4.1.5 and EC 3.1.2.6.
Cross-references
BRENDA4.2.1.130
EC2PDB4.2.1.130
ExplorEnz4.2.1.130
PRIAM enzyme-specific profiles4.2.1.130
KEGG Ligand Database for Enzyme Nomenclature4.2.1.130
IUBMB Enzyme Nomenclature4.2.1.130
IntEnz4.2.1.130
MEDLINEFind literature relating to 4.2.1.130
MetaCyc4.2.1.130
UniProtKB/Swiss-Prot
A7ZN88, HCHA_ECO24;  B7MCM0, HCHA_ECO45;  B7L8Y4, HCHA_ECO55;  
Q8XB78, HCHA_ECO57;  B5YSJ3, HCHA_ECO5E;  B7NRB5, HCHA_ECO7I;  
B7MWF3, HCHA_ECO81;  B7M3A5, HCHA_ECO8A;  C4ZQN7, HCHA_ECOBW;  
B1X6B7, HCHA_ECODH;  A8A1G6, HCHA_ECOHS;  A1ACB2, HCHA_ECOK1;  
Q0TGM8, HCHA_ECOL5;  P59331, HCHA_ECOL6;  B1IZU5, HCHA_ECOLC;  
P31658, HCHA_ECOLI;  B7NBV8, HCHA_ECOLU;  B6I112, HCHA_ECOSE;  
B1LQP2, HCHA_ECOSM;  Q1RAH5, HCHA_ECOUT;  B7UX51, HCHA_PSEA8;  
Q02IV5, HCHA_PSEAB;  Q9I4K0, HCHA_PSEAE;  B2TWL8, HCHA_SHIB3;  
Q0T3G3, HCHA_SHIF8;  P59332, HCHA_SHIFL;  Q3Z0M5, HCHA_SHISS;  
A7WYY0, HCHA_STAA1;  A6TZ28, HCHA_STAA2;  Q2FJ89, HCHA_STAA3;  
Q2G0M7, HCHA_STAA8;  A5IQA5, HCHA_STAA9;  Q2YSB0, HCHA_STAAB;  
Q5HIC4, HCHA_STAAC;  A6QEK3, HCHA_STAAE;  P64312, HCHA_STAAM;  
P64313, HCHA_STAAN;  Q6GJB7, HCHA_STAAR;  Q6GBT6, HCHA_STAAS;  
A8YZP8, HCHA_STAAT;  Q8NXY2, HCHA_STAAW;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
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