Expasy logo

ENZYME

ENZYME entry: EC 4.2.1.130

Accepted Name
D-lactate dehydratase
Alternative Name(s)
glyoxylase III
Reaction catalysed
H2O + methylglyoxal <=> (R)-lactate + H(+)
Comment(s)
  • The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step.
  • The other known route for this conversion is the two-step GSH- dependent pathway catalyzed by EC 4.4.1.5 and EC 3.1.2.6.
Cross-references
BRENDA4.2.1.130
EC2PDB4.2.1.130
ExplorEnz4.2.1.130
PRIAM enzyme-specific profiles4.2.1.130
KEGG Ligand Database for Enzyme Nomenclature4.2.1.130
IUBMB Enzyme Nomenclature4.2.1.130
IntEnz4.2.1.130
MEDLINEFind literature relating to 4.2.1.130
MetaCyc4.2.1.130
Rhea expert-curated reactions4.2.1.130
UniProtKB/Swiss-Prot
P90994, DJ11_CAEELO16228, DJ12_CAEELQ10356, DJ1_SCHPO
P31658, HCHA_ECOLIQ5AF03, HSP31_CANALO74914, HSP31_SCHPO
Q04432, HSP31_YEASTQ09675, HSP32_SCHPOQ08992, HSP32_YEAST
O43084, HSP33_SCHPOQ08914, HSP33_YEASTQ10092, HSP34_SCHPO
Q09918, HSP35_SCHPOQ04902, SNO4_YEAST

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-