ID   4.2.1.157
DE   (R)-2-hydroxyisocaproyl-CoA dehydratase.
AN   2-hydroxyisocaproyl-CoA dehydratase.
CA   (R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O.
CC   -!- The enzyme, isolated from the bacterium Peptoclostridium difficile,
CC       is involved in the reductive branch of L-leucine fermentation.
CC   -!- It catalyzes an alpha/beta-dehydration, which depends on the
CC       reductive formation of ketyl radicals on the substrate generated by
CC       injection of a single electron from the ATP-dependent activator
CC       protein HadI.
DR   Q5U924, HADB_CLODI ;  Q5U923, HADC_CLODI ;
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