ENZYME entry: EC 4.2.1.3

Accepted Name
Aconitate hydratase.
Alternative Name(s)
Aconitase.
Cis-aconitase.
Citrate hydro-lyase.
Citrate(isocitrate) hydro-lyase.
Reaction catalysed
Citrate <=> isocitrate
Cofactor(s)
Iron-sulfur.
Comment(s)
  • Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate.
  • The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate.
  • Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate.
  • Formerly EC 4.2.1.4.
Cross-references
PROSITEPDOC00423
BRENDA4.2.1.3
EC2PDB4.2.1.3
ExplorEnz4.2.1.3
PRIAM enzyme-specific profiles4.2.1.3
KEGG Ligand Database for Enzyme Nomenclature4.2.1.3
IUBMB Enzyme Nomenclature4.2.1.3
IntEnz4.2.1.3
MEDLINEFind literature relating to 4.2.1.3
MetaCyc4.2.1.3
UniProtKB/Swiss-Prot
Q42560, ACO1_ARATH;  Q9SIB9, ACO2M_ARATH;  Q94A28, ACO3M_ARATH;  
Q0VCU1, ACOC_BOVIN;  Q23500, ACOC_CAEEL;  Q90875, ACOC_CHICK;  
P49608, ACOC_CUCMA;  Q42669, ACOC_CUCMC;  Q54X73, ACOC_DICDI;  
P21399, ACOC_HUMAN;  P28271, ACOC_MOUSE;  Q6YZX6, ACOC_ORYSJ;  
Q01059, ACOC_RABIT;  Q63270, ACOC_RAT;  O04916, ACOC_SOLTU;  
Q5SMF6, ACOHO_THET8;  P25516, ACON1_ECOLI;  Q9I3F5, ACON1_PSEAE;  
P36683, ACON2_ECOLI;  Q9ZL64, ACON2_HELPJ;  P56418, ACON2_HELPY;  
Q9I2V5, ACON2_PSEAE;  P74582, ACON2_SYNY3;  Q4WLN1, ACON_ASPFU;  
P09339, ACON_BACSU;  P20004, ACON_BOVIN;  P70920, ACON_BRADU;  
P34455, ACON_CAEEL;  P82611, ACON_CANAL;  Q6NH63, ACON_CORDI;  
Q8FTA8, ACON_COREF;  Q8NQ98, ACON_CORGL;  Q4JVM4, ACON_CORJK;  
Q9RTN7, ACON_DEIRA;  Q54XS2, ACON_DICDI;  C8VG90, ACON_EMENI;  
Q2A1K3, ACON_FRATH;  P49609, ACON_GRAGA;  Q99798, ACON_HUMAN;  
P37032, ACON_LEGPH;  Q99KI0, ACON_MOUSE;  O08451, ACON_MYCAV;  
A0QX20, ACON_MYCS2;  P16276, ACON_PIG;  Q9ER34, ACON_RAT;  
Q1RKD5, ACON_RICBR;  Q92G90, ACON_RICCN;  Q4UK20, ACON_RICFE;  
Q9ZCF4, ACON_RICPR;  Q68VV0, ACON_RICTY;  O13966, ACON_SCHPO;  
Q5HG69, ACON_STAAC;  P63433, ACON_STAAM;  P99148, ACON_STAAN;  
Q6GH55, ACON_STAAR;  Q6G9K9, ACON_STAAS;  P63434, ACON_STAAW;  
Q5HPJ0, ACON_STAEQ;  Q8CPC2, ACON_STAES;  Q59938, ACON_STRMU;  
P19414, ACON_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
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