ENZYME entry: EC 4.2.1.36

Accepted Name
Homoaconitate hydratase.
Alternative Name(s)
2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase.
Cis-homoaconitase.
HACN.
Homoaconitase.
Reaction catalysed
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H(2)O
Cofactor(s)
Iron-sulfur.
Comment(s)
  • The enzyme from the hyperthermophilic eubacterium Thermus thermophilus can catalyze the reaction shown above but cannot catalyze the previously described reaction, i.e. formation of homocitrate by hydration of cis-homoaconitate.
  • The enzyme responsible for the conversion of cis-homoaconitate into homocitrate in T.thermophilus is unknown at present but the reaction can be catalyzed in vitro using EC 4.2.1.3 from pig.
Cross-references
PROSITEPDOC00423
BRENDA4.2.1.36
EC2PDB4.2.1.36
ExplorEnz4.2.1.36
PRIAM enzyme-specific profiles4.2.1.36
KEGG Ligand Database for Enzyme Nomenclature4.2.1.36
IUBMB Enzyme Nomenclature4.2.1.36
IntEnz4.2.1.36
MEDLINEFind literature relating to 4.2.1.36
MetaCyc4.2.1.36
UniProtKB/Swiss-Prot
Q58409, HACA_METJA;  Q9ZNE0, HACA_THET2;  Q58667, HACB_METJA;  
Q9ZND9, HACB_THET2;  Q75DX9, LYS4_ASHGO;  Q4WUL6, LYS4_ASPFU;  
Q58FL6, LYS4_ASPNC;  Q2U9G3, LYS4_ASPOR;  Q5A644, LYS4_CANAL;  
Q6FM51, LYS4_CANGA;  Q2HZ33, LYS4_CANPA;  Q2GN26, LYS4_CHAGB;  
P0CM03, LYS4_CRYNB;  P0CM02, LYS4_CRYNJ;  Q6BM98, LYS4_DEBHA;  
Q92412, LYS4_EMENI;  Q4HVQ9, LYS4_GIBZE;  Q6CT61, LYS4_KLULA;  
Q870W1, LYS4_NEUCR;  Q9UT74, LYS4_SCHPO;  Q4P521, LYS4_USTMA;  
Q6C791, LYS4_YARLI;  P49367, LYS4_YEAST;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-