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ENZYME entry: EC 4.2.1.47

Accepted Name
GDP-mannose 4,6-dehydratase.
Alternative Name(s)
GDP-D-mannose 4,6-dehydratase.
GDP-D-mannose dehydratase.
Guanosine 5'-diphosphate-D-mannose oxidoreductase.
Guanosine diphosphomannose 4,6-dehydratase.
Guanosine diphosphomannose oxidoreductase.
Reaction catalysed
GDP-alpha-D-mannose <=> GDP-4-dehydro-alpha-D-rhamnose + H(2)O
Cofactor(s)
NAD(+).
Comment(s)
  • Forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-alpha-L-fucose.
  • In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalyzing the above reaction as well as the reaction catalyzed by EC 1.1.1.281.
Cross-references
BRENDA4.2.1.47
EC2PDB4.2.1.47
ExplorEnz4.2.1.47
PRIAM enzyme-specific profiles4.2.1.47
KEGG Ligand Database for Enzyme Nomenclature4.2.1.47
IUBMB Enzyme Nomenclature4.2.1.47
IntEnz4.2.1.47
MEDLINEFind literature relating to 4.2.1.47
MetaCyc4.2.1.47
UniProtKB/Swiss-Prot
Q9JRN5, GM4D_AGGAC;  P0AC90, GM4D_ECO57;  P0AC89, GM4D_ECOL6;  
P0AC88, GM4D_ECOLI;  Q51366, GM4D_PSEAE;  O85713, GM4D_RHIFH;  
P0AC91, GM4D_SHIFL;  P55354, GM4D_SINFN;  Q06952, GM4D_VIBCH;  
Q56598, GM4D_VIBCL;  Q56872, GM4D_YERE8;  Q9SNY3, GMD1_ARATH;  
A8Y0L5, GMD1_CAEBR;  Q18801, GMD1_CAEEL;  P93031, GMD2_ARATH;  
O45583, GMD2_CAEEL;  Q8K3X3, GMDS_CRIGR;  Q1ZXF7, GMDS_DICDI;  
Q9VMW9, GMDS_DROME;  O60547, GMDS_HUMAN;  Q8K0C9, GMDS_MOUSE;  
A0A1B4XBH2, SDNI_SORAA;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-