ENZYME entry: EC 4.2.1.70

Accepted Name
Pseudouridylate synthase.
Alternative Name(s)
Pseudouridine synthase.
Pseudouridine-5'-phosphate glycosidase.
Uracil hydrolyase.
Reaction catalysed
Uracil + D-ribose 5-phosphate <=> pseudouridine 5'-phosphate + H(2)O
Comment(s)
  • The reaction it readily reversible.
  • While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo.
Cross-references
PROSITEPDOC00869 ; PDOC00885
BRENDA4.2.1.70
EC2PDB4.2.1.70
ExplorEnz4.2.1.70
PRIAM enzyme-specific profiles4.2.1.70
KEGG Ligand Database for Enzyme Nomenclature4.2.1.70
IUBMB Enzyme Nomenclature4.2.1.70
IntEnz4.2.1.70
MEDLINEFind literature relating to 4.2.1.70
MetaCyc4.2.1.70
UniProtKB/Swiss-Prot
Q7N4X5, PSUG1_PHOLL;  Q1MFZ6, PSUG1_RHIL3;  Q7MZE1, PSUG2_PHOLL;  
Q1M4T3, PSUG2_RHIL3;  A9NGD7, PSUG_ACHLI;  A6TL60, PSUG_ALKMQ;  
B8JB61, PSUG_ANAD2;  C0QZV6, PSUG_BRAHW;  C0ZIY1, PSUG_BREBN;  
Q8RCT3, PSUG_CALS4;  B9LGZ1, PSUG_CHLSY;  A7GCK7, PSUG_CLOBL;  
B5Y6G9, PSUG_COPPD;  B3GW58, PSUG_CORA7;  Q46PS3, PSUG_CUPPJ;  
Q9RS16, PSUG_DEIRA;  C6CFY1, PSUG_DICZE;  A8LQI0, PSUG_DINSH;  
P33025, PSUG_ECOLI;  A7HMA1, PSUG_FERNB;  Q0RBB8, PSUG_FRAAA;  
C1AA54, PSUG_GEMAT;  Q5L078, PSUG_GEOKA;  B8F668, PSUG_HAEPS;  
Q2SM69, PSUG_HAHCH;  A9B4S4, PSUG_HERA2;  Q28PY7, PSUG_JANSC;  
C5CDZ1, PSUG_KOSOT;  Q5ZU79, PSUG_LEGPH;  B1HV79, PSUG_LYSSC;  
B8II14, PSUG_METNO;  A5IXG3, PSUG_MYCAP;  Q1D739, PSUG_MYXXD;  
A1SQN1, PSUG_NOCSJ;  A1B316, PSUG_PARDP;  A9BJN0, PSUG_PETMO;  
Q98NQ8, PSUG_RHILO;  B6IRJ4, PSUG_RHOCS;  Q165S4, PSUG_ROSDO;  
A5UT22, PSUG_ROSS1;  Q1AYR4, PSUG_RUBXD;  A4F929, PSUG_SACEN;  
A4X4Y7, PSUG_SALTO;  A8GCG3, PSUG_SERP5;  Q01RY8, PSUG_SOLUE;  
A9GT78, PSUG_SORC5;  Q8NYD0, PSUG_STAAW;  B1W0X1, PSUG_STRGG;  
Q67N11, PSUG_SYMTH;  B7ID34, PSUG_THEAB;  A8F8N4, PSUG_THELT;  
Q9X1H5, PSUG_THEMA;  B9K8C2, PSUG_THENN;  A5IMC0, PSUG_THEP1;  
B1LBK3, PSUG_THESQ;  Q72JF9, PSUG_THET2;  Q9USY1, YOW5_SCHPO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
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