ID   4.2.1.78
DE   (S)-norcoclaurine synthase.
AN   (S)-norlaudanosoline synthase.
CA   Dopamine + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H(2)O.
CC   -!- The reaction makes a 6-membered ring by forming a bond between C-6 of
CC       the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde
CC       in the imine formed between the substrates.
CC   -!- The product is the precursor of the benzylisoquinoline alkaloids in
CC       plants.
CC   -!- Will also catalyze the reaction of 4-(2-aminoethyl)benzene-1,2-diol +
CC       (3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline,
CC       but this alkaloid has not been found to occur in plants.
PR   PROSITE; PDOC51471;
DR   A2A1A0, NCS1_COPJA ;  A2A1A1, NCS2_COPJA ;  Q67A25, NCS_THLFG  ;
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