ENZYME entry: EC 4.2.1.92

Accepted Name
Hydroperoxide dehydratase.
Alternative Name(s)
Allene oxide synthase.
AOS.
Hydroperoxide isomerase.
Reaction catalysed
(9Z,11E,15Z)-(13S)-hydroperoxyoctadeca-9,11,15-trienoate <=> (9Z,15Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides.
  • The product of the above reaction is unstable and is acted upon by EC 5.3.99.6 to form the cyclopentenone derivative (15Z)-12-oxophyto- 10,15-dienoate (OPDA), which is the first cyclic and biologically active metabolite in the jasmonate biosynthesis pathway.
Cross-references
PROSITEPDOC00081
BRENDA4.2.1.92
EC2PDB4.2.1.92
ExplorEnz4.2.1.92
PRIAM enzyme-specific profiles4.2.1.92
KEGG Ligand Database for Enzyme Nomenclature4.2.1.92
IUBMB Enzyme Nomenclature4.2.1.92
IntEnz4.2.1.92
MEDLINEFind literature relating to 4.2.1.92
MetaCyc4.2.1.92
UniProtKB/Swiss-Prot
O16025, AOSL_PLEHO;  Q7Y0C8, C74A1_ORYSJ;  Q7XYS3, C74A2_ORYSJ;  
Q40778, C74A2_PARAR;  Q6Z6L1, C74A3_ORYSJ;  Q6Z6K9, C74A4_ORYSJ;  
Q96242, CP74A_ARATH;  P48417, CP74_LINUS;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-