ENZYME entry: EC 4.2.2.5

Accepted Name
Chondroitin AC lyase.
Alternative Name(s)
Chondroitin AC eliminase.
Chondroitin sulfate lyase.
Chondroitinase.
Reaction catalysed
Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups
Comment(s)
  • Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate.
  • In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region.
  • The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta-1- 3)GalNAc(beta-1-](n), which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA.
  • GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha-1-3)GalNAc(beta-1-](n) of DS.
  • Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source.
  • Formerly EC 4.2.99.6.
Cross-references
BRENDA4.2.2.5
EC2PDB4.2.2.5
ExplorEnz4.2.2.5
PRIAM enzyme-specific profiles4.2.2.5
KEGG Ligand Database for Enzyme Nomenclature4.2.2.5
IUBMB Enzyme Nomenclature4.2.2.5
IntEnz4.2.2.5
MEDLINEFind literature relating to 4.2.2.5
MetaCyc4.2.2.5
UniProtKB/Swiss-Prot
Q59288, CSLA_PEDHD

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.2.-
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