ENZYME

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ENZYME entry: EC 4.2.2.5

Accepted Name

Chondroitin AC lyase.

Alternative Name(s)

Chondroitin AC eliminase.

Chondroitin sulfate lyase.

Chondroitinase.

Reaction catalysed

Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups

Comment(s)

Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate.
In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region.
The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta-1- 3)GalNAc(beta-1-](n), which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA.
GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha-1-3)GalNAc(beta-1-](n) of DS.
Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source.
Formerly EC 4.2.99.6.

Cross-references

BRENDA

4.2.2.5

EC2PDB

4.2.2.5

ExplorEnz

4.2.2.5

PRIAM enzyme-specific profiles

4.2.2.5

KEGG Ligand Database for Enzyme Nomenclature

4.2.2.5

IUBMB Enzyme Nomenclature