ENZYME entry: EC 4.2.3.119

Accepted Name
(-)-alpha-pinene synthase.
Alternative Name(s)
(-)-alpha-pinene cyclase.
(-)-alpha-pinene/(-)-camphene synthase.
Reaction catalysed
Geranyl-diphosphate <=> (-)-alpha-pinene + diphosphate
Comment(s)
  • Cyclase II of Salvia officinalis (sage) gives about equal parts (-)- alpha-pinene, (-)-beta-pinene and (-)-camphene, plus traces of other monoterpenoids.
  • (3S)-Linalyl diphosphate can also be used by the enzyme in preference to (3R)-linalyl diphosphate.
  • The 4-pro-S-hydrogen of geranyl diphosphate is lost.
  • The enzyme from Abies grandis (grand fir) gives roughly equal parts (-)-alpha-pinene and (-)-beta-pinene.
  • However the clone ag11 gave 35% (-)-limonene, 24% (-)-alpha-pinene and 20% (-)-beta-phellandrene.
  • Synthase I from Pinus taeda (loblolly pine) produces (-)-alpha-pinene with traces of (-)-beta-pinene.
  • The enzyme from Picea sitchensis (Sika spruce) forms 70% (-)-alpha- pinene and 30% (-)-beta-pinene.
  • The recombinant PmeTPS1 enzyme from Pseudotsuga menziesii (Douglas fir) gave roughly equal proportions of (-)-alpha-pinene and (-)- camphene plus traces of other monoterpenoids.
  • See also EC 4.2.3.120, EC 4.2.3.117, EC 4.2.3.16, and EC 4.2.3.52.
  • Formerly EC 4.1.99.8, EC 4.2.3.14, and EC 4.2.3.n7.
Cross-references
BRENDA4.2.3.119
EC2PDB4.2.3.119
ExplorEnz4.2.3.119
PRIAM enzyme-specific profiles4.2.3.119
KEGG Ligand Database for Enzyme Nomenclature4.2.3.119
IUBMB Enzyme Nomenclature4.2.3.119
IntEnz4.2.3.119
MEDLINEFind literature relating to 4.2.3.119
MetaCyc4.2.3.119
UniProtKB/Swiss-Prot
O23945, PINS_FRAVE;  Q84KL6, PT1_PINTA;  Q6XDB5, TPSD2_PICSI;  
O24475, TPSD3_ABIGR;  Q9M7C9, TPSDB_ABIGR;  

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