ENZYME entry: EC 4.2.3.12

Accepted Name
6-pyruvoyltetrahydropterin synthase.
Alternative Name(s)
6-pyruvoyl tetrahydrobiopterin synthase.
PTPS.
Reaction catalysed
7,8-dihydroneopterin 3'-triphosphate <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • Catalyzes triphosphate elimination and an intramolecular redox reaction.
  • The product is 6-pyruvoyltetrahydrobiopterin.
  • Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 3.5.4.16.
  • Formerly EC 4.6.1.10.
Cross-references
PROSITEPDOC00759
BRENDA4.2.3.12
EC2PDB4.2.3.12
ExplorEnz4.2.3.12
PRIAM enzyme-specific profiles4.2.3.12
KEGG Ligand Database for Enzyme Nomenclature4.2.3.12
IUBMB Enzyme Nomenclature4.2.3.12
IntEnz4.2.3.12
MEDLINEFind literature relating to 4.2.3.12
MetaCyc4.2.3.12
UniProtKB/Swiss-Prot
O02058, PTPS_CAEEL;  Q1ZXI0, PTPS_DICDI;  P48611, PTPS_DROME;  
Q03393, PTPS_HUMAN;  Q9R1Z7, PTPS_MOUSE;  Q90W95, PTPS_POERE;  
Q5REZ5, PTPS_PONAB;  P27213, PTPS_RAT;  P80081, PTPS_SALSA;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-